Positive end-expiratory pressure improves elastic working pressure in anesthetized children

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dc.contributor.authorCruces, P.
dc.contributor.authorGonzález-Dambrauskas, S.
dc.contributor.authorCristiani, F.
dc.contributor.authorMartínez, J.
dc.contributor.authorHenderson, R.
dc.contributor.authorErranz, B.
dc.contributor.authorDíaz, F.
dc.date.accessioned2019-12-13T18:10:53Z
dc.date.available2019-12-13T18:10:53Z
dc.date.issued2018-10
dc.descriptionIndexación: Scopus.es
dc.descriptionThis work was supported by CONICYT #1160631 (Dr. Cruces) and CONICYT. #11160463 (Dr. Diaz) grants. These grants were involved in design of the study, collection of data, writing the manuscript and manuscript language edition services.
dc.description.abstractBackground: Positive end-expiratory pressure (PEEP) has been demonstrated to decrease ventilator-induced lung injury in patients under mechanical ventilation (MV) for acute respiratory failure. Recently, some studies have proposed some beneficial effects of PEEP in ventilated patients without lung injury. The influence of PEEP on respiratory mechanics in children is not well known. Our aim was to determine the effects on respiratory mechanics of setting PEEP at 5 cmH2O in anesthetized healthy children. Methods: Patients younger than 15 years old without history of lung injury scheduled for elective surgery gave informed consent and were enrolled in the study. After usual care for general anesthesia, patients were placed on volume controlled MV. Two sets of respiratory mechanics studies were performed using inspiratory and expiratory breath hold, with PEEP 0 and 5 cmH2O. The maximum inspiratory and expiratory flow (QI and QE) as well as peak inspiratory pressure (PIP), plateau pressure (PPL) and total PEEP (tPEEP) were measured. Respiratory system compliance (CRS), inspiratory and expiratory resistances (RawI and RawE) and time constants (KTI and KTE) were calculated. Data were expressed as median and interquartile range (IQR). Wilcoxon sign test and Spearman's analysis were used. Significance was set at P < 0.05. Results: We included 30 patients, median age 39 (15-61.3) months old, 60% male. When PEEP increased, PIP increased from 12 (11,14) to 15.5 (14,18), and CRS increased from 0.9 (0.9,1.2) to 1.2 (0.9,1.4) mL·kg- 1·cmH2O- 1; additionally, when PEEP increased, driving pressure decreased from 6.8 (5.9,8.1) to 5.8 (4.7,7.1) cmH2O, and QE decreased from 13.8 (11.8,18.7) to 11.7 (9.1,13.5) L·min- 1 (all P < 0.01). There were no significant changes in resistance and QI. Conclusions: Analysis of respiratory mechanics in anesthetized healthy children shows that PEEP at 5 cmH2O places the respiratory system in a better position in the P/V curve. A better understanding of lung mechanics may lead to changes in the traditional ventilatory approach, limiting injury associated with MV. © 2018 The Author(s).es
dc.description.urihttps://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-018-0611-8
dc.identifier.citationBMC Anesthesiology, 18(1), art. no. 151.es
dc.identifier.issn1471-2253
dc.identifier.otherDOI: 10.1186/s12871-018-0611-8
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11460
dc.language.isoenes
dc.publisherBioMed Centrales
dc.subjectMechanical ventilationes
dc.subjectPediatricses
dc.subjectPositive end-expiratory pressurees
dc.subjectRespiratory mechanicses
dc.titlePositive end-expiratory pressure improves elastic working pressure in anesthetized childrenes
dc.typeArtículoes
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