Mesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities

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dc.contributor.authorVukotić, M.
dc.contributor.authorKapor, S.
dc.contributor.authorSimon, F.
dc.contributor.authorCokic, V.
dc.contributor.authorSantibanez, J.
dc.date.accessioned2024-09-11T14:47:03Z
dc.date.available2024-09-11T14:47:03Z
dc.date.issued2024-02
dc.descriptionTEXTO COMPLETO EN INGLÉS
dc.description.abstractMyeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, including acute myeloid leukemia, myelodysplastic syndromes, myeloproliferative malignancies, and chronic myelomonocytic leukemia. Myeloid neoplastic cells affect the proliferation and differentiation of other hematopoietic lineages in the bone marrow and peripheral blood, leading to severe and life-threatening complications. Mesenchymal stromal cells (MSCs) residing in the bone marrow exert immunosuppressive functions by suppressing innate and adaptive immune systems, thus creating a supportive and tolerant microenvironment for myeloid malignancy progression. This review summarizes the significant features of MSCs in myeloid malignancies, including their role in regulating cell growth, cell death, and antineoplastic resistance, in addition to their immunosuppressive contributions. Understanding the implications of MSCs in myeloid malignancies could pave the path for potential use in immunotherapy.
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S2405844024011125
dc.identifier.citationHeliyon, Volume 10, Issue 3 , 15 February 2024, e25081
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2024.e25081
dc.identifier.issn2405-8440
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60077
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseAttribution 4.0 International
dc.subjectyeloid malignancies
dc.subjectMyeloid cells
dc.subjectMesenchymal stromal cells
dc.subjectCell differentiation
dc.subjectT-cell immunosuppression therapy
dc.titleMesenchymal stromal cells in myeloid malignancies: Immunotherapeutic opportunities
dc.typeArtículo
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