αVβ3 Integrin regulates astrocyte reactivity

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dc.contributor.authorLagos-Cabré, Raúl
dc.contributor.authorAlvarez, Alvaro
dc.contributor.authorKong, Milene
dc.contributor.authorBurgos-Bravo, Francesca
dc.contributor.authorCárdenas, Areli
dc.contributor.authorRojas-Mancilla, Edgardo
dc.contributor.authorPérez-Nuñez, Ramón
dc.contributor.authorHerrera-Molina, Rodrigo
dc.contributor.authorRojas, Fabiola
dc.contributor.authorSchneider, Pascal
dc.contributor.authorHerrera-Marschitz, Mario
dc.contributor.authorQuest, Andrew F.G.
dc.contributor.authorvan Zundert, Brigitte
dc.contributor.authorLeyton, Lisette
dc.date.accessioned2024-03-26T15:54:23Z
dc.date.available2024-03-26T15:54:23Z
dc.date.issued2017-09
dc.descriptionIndexación: Scopus
dc.description.abstractBackground: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4. Primary astrocytes express low levels of these receptors and are unresponsive to Thy-1; thus, inflammation and astrocyte reactivity might be necessary for Thy-1-induced responses. Methods: Wild-type rat astrocytes (TNF-activated) or from human SOD1G93A transgenic mice (a neurodegenerative disease model) were used to evaluate cell migration, Thy-1 receptor levels, signaling molecules, and reactivity markers. Results: Thy-1 induced astrocyte migration only after TNF priming. Increased expression of αVβ3 Integrin, Syndecan-4, P2X7R, Pannexin-1, Connexin-43, GFAP, and iNOS were observed in TNF-treated astrocytes. Silencing of β3 Integrin prior to TNF treatment prevented Thy-1-induced migration, while β3 Integrin over-expression was sufficient to induce astrocyte reactivity and allow Thy-1-induced migration. Finally, hSOD1G93A astrocytes behave as TNF-treated astrocytes since they were reactive and responsive to Thy-1. Conclusions: Therefore, inflammation induces expression of αVβ3 Integrin and other proteins, astrocyte reactivity, and Thy-1 responsiveness. Importantly, ectopic control of β3 Integrin levels modulates these responses regardless of inflammation. © 2017 The Author(s).
dc.identifier.citationJournal of Neuroinflammation Volume 14, Issue 129 September 2017 Article number 194
dc.identifier.issn1742-2094
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55320
dc.language.isoen
dc.publisherJournal
dc.subjectAmyotrophic lateral sclerosis
dc.subjectCell migration
dc.subjectInflammation
dc.subjectIntegrins
dc.subjectReactive astrocytes
dc.titleαVβ3 Integrin regulates astrocyte reactivity
dc.typeArtículo
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