Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG

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dc.contributor.authorBueno, Susan M.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorCautivo, Kelly M.
dc.contributor.authorMora, Jorge E.
dc.contributor.authorLeiva, Eduardo D.
dc.contributor.authorTobar, Hugo E.
dc.contributor.authorFennelly, Glenn J.
dc.contributor.authorEugenin, Eliseo A.
dc.contributor.authorJacobs Jr., William R.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-04-05T21:29:13Z
dc.date.available2024-04-05T21:29:13Z
dc.date.issued2008-12-30
dc.descriptionINDEXACIÓN: SCOPUS.
dc.description.abstractRespiratory syncytial virus (RSV) is one of the leading causes of childhood hospitalization and a major health burden worldwide. Unfortunately, because of an inefficient immunological memory, RSV infection provides limited immune protection against reinfection. Furthermore, RSV can induce an inadequate Th2-type immune response that causes severe respiratory tract inflammation and obstruction. It is thought that effective RSV clearance requires the induction of balanced Th1-type immunity, involving the activation of IFN-γ-secreting cytotoxic T cells. A recognized inducer of Th1 immunity is Mycobacterium bovis bacillus Calmette-Guérin (BCG), which has been used in newborns for decades in several countries as a tuberculosis vaccine. Here, we show that immunization with recombinant BCG strains expressing RSV antigens promotes protective Th1-type immunity against RSV in mice. Activation of RSV-specific T cells producing IFN-γ and IL-2 was efficiently obtained after immunization with recombinant BCG. This type of T cell immunity was protective against RSV challenge and caused a significant reduction of inflammatory cell infiltration in the airways. Furthermore, mice immunized with recombinant BCG showed no weight loss and reduced lung viral loads. These data strongly support recombinant BCG as an efficient vaccine against RSV because of its capacity to promote protective Th1 immunity. © 2008 by The National Academy of Sciences of the USA.
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, Volume 105, Issue 52, Pages 20822 - 20827, 30 December 2008
dc.identifier.doi10.1073/pnas.0806244105
dc.identifier.issn1091-6490
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55732
dc.language.isoen
dc.publisherNational Academy of Sciences
dc.rights.licenseCC BY-NC-ND 4.0 DEED Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectImmunopathology
dc.subjectRSV
dc.subjectT cell immunity
dc.subjectTh1 cell response
dc.titleProtective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG
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