Macrophage–Neisseria gonorrhoeae Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulation

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dc.contributor.authorEscobar, Alejandro
dc.contributor.authorRodas, Paula
dc.contributor.authorAcuña-Castillo, Claudio
dc.date.accessioned2022-06-17T18:47:46Z
dc.date.available2022-06-17T18:47:46Z
dc.date.issued2018-12
dc.descriptionIndexación Scopuses
dc.description.abstractNeisseria gonorrhoeae is a significant health problem worldwide due to multi-drug resistance issues and absence of an effective vaccine. Patients infected with N. gonorrhoeae have not shown a better immune response in successive infections. This might be explained by the fact that N. gonorrhoeae possesses several mechanisms to evade the innate and adaptative immune responses at different levels. Macrophages are a key cellular component in the innate immune response against microorganisms. The current information suggests that gonococcus can hijack the host response by mechanisms that involve the control of macrophages activity. In this mini review, we intend to condense the recent knowledge on the macrophage–N. gonorrhoeae interactions with a focus on strategies developed by gonococcus to evade or to exploit immune response to establish a successful infection. Finally, we discuss the opportunities and challenges of therapeutics for controlling immune manipulation by N. gonorrhoeae. © Copyright © 2018 Escobar, Rodas and Acuña-Castillo.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.03044/full
dc.identifier.citationFrontiers in Immunology, Volume 921 December 2018 Article number 3044es
dc.identifier.doi10.3389/fimmu.2018.03044
dc.identifier.issn16643224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22899
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseCC BY 4.0
dc.subjectNeisseriaes
dc.subjectAnimalses
dc.subjectGonorrhoeaes
dc.subjectHost responsees
dc.subjectImmunomodulationes
dc.titleMacrophage–Neisseria gonorrhoeae Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulationes
dc.typeArtículoes
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