Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Vista sencilla de ítem
dc.contributor.authorCabané, Patricio
dc.contributor.authorCorrea, Claudio
dc.contributor.authorBode, Ignacio
dc.contributor.authorAguilar, Rodrigo
dc.contributor.authorElorza, Alvaro A.
dc.date.accessioned2024-07-10T13:15:05Z
dc.date.available2024-07-10T13:15:05Z
dc.date.issued2024-06
dc.descriptionIndexación: Scopus.
dc.description.abstractThyroid cancer diagnosis primarily relies on imaging techniques and cytological analyses. In cases where the diagnosis is uncertain, the quantification of molecular markers has been incorporated after cytological examination. This approach helps physicians to make surgical decisions, estimate cancer aggressiveness, and monitor the response to treatments. Despite the availability of commercial molecular tests, their widespread use has been hindered in our experience due to cost constraints and variability between them. Thus, numerous groups are currently evaluating new molecular markers that ultimately will lead to improved diagnostic certainty, as well as better classification of prognosis and recurrence. In this review, we start reviewing the current preoperative testing methodologies, followed by a comprehensive review of emerging molecular markers. We focus on micro RNAs, long non-coding RNAs, and mitochondrial (mt) signatures, including mtDNA genes and circulating cell-free mtDNA. We envision that a robust set of molecular markers will complement the national and international clinical guides for proper assessment of the disease.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85197200413&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=e0561592176c52c7ad670dc1a7a6893a&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID%28%22Universidad+Andr%c3%a9s+Bello%22+60002636%29+AND+SUBJAREA%28COMP%29&relpos=6&citeCnt=0&searchTerm=
dc.identifier.citationInternational Journal of Molecular Sciences Open Access Volume 25, Issue 12 June 2024 Article number 6719
dc.identifier.doi10.3390/ijms25126719
dc.identifier.issn16616596
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/58394
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdiagnosis
dc.subjectmitochondria
dc.subjectmolecular markers
dc.subjectnon-coding RNAs
dc.subjectthyroid cancer
dc.titleBiomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Cabane-P-Biomarkers-in-Thyroid-Cancer-Emerging-Opportunities-from-NonCoding-RNAs-and-Mitochondrial-Space.pdf
Tamaño:
409.32 KB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista