Acidithiobacillus ferrooxidans metabolism: From genome sequence to industrial applications

Vista sencilla de ítem
dc.contributor.authorValdés, Jorge
dc.contributor.authorPedroso, Inti
dc.contributor.authorQuatrini, Raquel
dc.contributor.authorDodson, Robert J.
dc.contributor.authorTettelin, Herve
dc.contributor.authorBlake II, Robert
dc.contributor.authorEisen, Jonathan A.
dc.contributor.authorHolmes, David S.
dc.date.accessioned2024-04-05T20:58:44Z
dc.date.available2024-04-05T20:58:44Z
dc.date.issued2008-12-11
dc.descriptionINDEXACIÓN: SCOPUS.
dc.description.abstractBackground: Acidithiobacillus ferrooxidans is a major participant in consortia of microorganisms used for the industrial recovery of copper (bioleaching or biomining). It is a chemolithoautrophic, γ-proteobacterium using energy from the oxidation of iron- and sulfur-containing minerals for growth. It thrives at extremely low pH (pH 1-2) and fixes both carbon and nitrogen from the atmosphere. It solubilizes copper and other metals from rocks and plays an important role in nutrient and metal biogeochemical cycling in acid environments. The lack of a well-developed system for genetic manipulation has prevented thorough exploration of its physiology. Also, confusion has been caused by prior metabolic models constructed based upon the examination of multiple, and sometimes distantly related, strains of the microorganism. Results: The genome of the type strain A. ferrooxidans ATCC 23270 was sequenced and annotated to identify general features and provide a framework for in silico metabolic reconstruction. Earlier models of iron and sulfur oxidation, biofilm formation, quorum sensing, inorganic ion uptake, and amino acid metabolism are confirmed and extended. Initial models are presented for central carbon metabolism, anaerobic metabolism (including sulfur reduction, hydrogen metabolism and nitrogen fixation), stress responses, DNA repair, and metal and toxic compound fluxes. Conclusion: Bioinformatics analysis provides a valuable platform for gene discovery and functional prediction that helps explain the activity of A. ferrooxidans in industrial bioleaching and its role as a primary producer in acidic environments. An analysis of the genome of the type strain provides a coherent view of its gene content and metabolic potential. © 2008 Valdés et al; licensee BioMed Central Ltd.
dc.identifier.citationBMC Genomics, Volume 9, 11 December 2008, Article number 597
dc.identifier.doi10.1186/1471-2164-9-597
dc.identifier.issn1471-2164
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55730
dc.language.isoen
dc.publisherBMC
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAcidithiobacillus
dc.subjectComputational Biology
dc.subjectGenes, Bacterial
dc.subjectGenome, Bacterial
dc.subjectIndustrial Microbiology
dc.subjectMolecular Sequence Data
dc.subjectMultigene Family
dc.titleAcidithiobacillus ferrooxidans metabolism: From genome sequence to industrial applications
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Acidithiobacillus-ferrooxidans-metabolism-From-genome-sequence-to-industrial-applicationsBMC-Genomics.pdf
Tamaño:
8.56 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS.
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista