Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

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dc.contributor.authorMontero, David A.
dc.contributor.authorVidal, Roberto M.
dc.contributor.authorVelasco, Juliana
dc.contributor.authorGeorge, Sergio
dc.contributor.authorLucero, Yalda
dc.contributor.authorGómez, Leonardo A.
dc.contributor.authorCarreño, Leandro J.
dc.contributor.authorGarcía-Betancourt, Richard
dc.contributor.authorO’Ryan, Miguel
dc.date.accessioned2024-04-05T16:14:28Z
dc.date.available2024-04-05T16:14:28Z
dc.date.issued2023
dc.descriptionIndexación: Scopus.
dc.description.abstractVibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease affecting millions worldwide each year. Cholera is a major public health problem, primarily in countries with poor sanitary conditions and regions affected by natural disasters, where access to safe drinking water is limited. In this narrative review, we aim to summarize the current understanding of the evolution of virulence and pathogenesis of V. cholerae as well as provide an overview of the immune response against this pathogen. We highlight that V. cholerae has a remarkable ability to adapt and evolve, which is a global concern because it increases the risk of cholera outbreaks and the spread of the disease to new regions, making its control even more challenging. Furthermore, we show that this pathogen expresses several virulence factors enabling it to efficiently colonize the human intestine and cause cholera. A cumulative body of work also shows that V. cholerae infection triggers an inflammatory response that influences the development of immune memory against cholera. Lastly, we reviewed the status of licensed cholera vaccines, those undergoing clinical evaluation, and recent progress in developing next-generation vaccines. This review offers a comprehensive view of V. cholerae and identifies knowledge gaps that must be addressed to develop more effective cholera vaccines. Copyright © 2023 Montero, Vidal, Velasco, George, Lucero, Gómez, Carreño, García-Betancourt and O’Ryan.
dc.identifier.citationFrontiers in Medicine. Volume 10. 2023. Article number 1155751
dc.identifier.issn2296-858X
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55693
dc.language.isoen
dc.publisherFrontiers Media SA
dc.subjectCholera
dc.subjectCholera toxin
dc.subjectDiarrhea
dc.subjectNext-generation vaccines
dc.subjectOral vaccine
dc.subjectVibrio cholerae
dc.titleVibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development
dc.typeArtículo
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