Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications

Vista sencilla de ítem
dc.contributor.authorVilos, Cristian
dc.contributor.authorGutiérrez, Marlen
dc.contributor.authorEscobar, Roberto A.
dc.contributor.authorMorales, Francisco
dc.contributor.authorDenardin, Juliano C.
dc.contributor.authorVelasquez, Luis
dc.contributor.authorAltbir, Dora
dc.date.accessioned2014-03-21T14:03:11Z
dc.date.accessioned2016-05-31T17:45:35Z
dc.date.available2014-03-21T14:03:11Z
dc.date.available2016-05-31T17:45:35Z
dc.date.issued2013
dc.descriptionIndexación: Scieloes
dc.description.abstractBackground: The progress in material science and the recent advances in biodegradable/biocompatible polymers and magnetic iron oxide nanoparticles have led to develop innovative diagnostic and therapeutic strategies for diseases based on multifunctional nanoparticles, which include contrast medium for magnetic resonance imaging, agent for hyperthermia and nanocarriers for targeted drug delivery. The aim of this work is to synthesize and characterize superparamagnetic iron oxide (magnetite), and to encapsulate them into poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles for biomedical applications. Results: The magnetite nanoparticles were confirmed by X-ray diffraction and exhibited a size of 22.3 ± 8.8 nm measured by transmission electron microscopy (TEM). Polymeric PHBV nanoparticles loaded with magnetite (MgNPs) were analyzed using dynamic light scattering and showed a size of 258.6 ± 35.7 nm and a negative zeta potential (-10.8 ± 3.5 mV). The TEM examination of MgNPs exhibited a spherical core-shell structure and the magnetic measurements showed in both, non-encapsulated magnetite and MgNPs, a superparamagnetic performance. Finally, the in vitro studies about the magnetic retention of MgNPs in a segment of small intestine of rats showed an active accumulation in the region of the magnetic field. Conclusions: The results obtained make the MgNPs suitable as potential magnetic resonance imaging contrast agents, also promoting hyperthermia and even as potential nanocarriers for site-specific transport and delivery of drugs. Keywords: hyperthermia, magnetic resonance image (MRI), magnetite, PHBV, polymeric nanoparticles.es
dc.description.urihttp://ref.scielo.org/cxt57w
dc.identifier.citationElectronic Journal of Biotechnology. Vol. 16. N° 5, Valparaíso, 2013.es
dc.identifier.issn0717-3458
dc.identifier.issnhttp://dx.doi.org/10.2225/vol16-issue5-fulltext-8
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2421
dc.language.isoenes
dc.publisherPontificia Universidad Católica de Valparaísoes
dc.subjecthyperthermia, magnetic resonance image (MRI), magnetite, PHBV, polymeric nanoparticles.es
dc.titleSuperparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applicationses
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Vilos_Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications_2013.pdf
Tamaño:
341.35 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 2 de 2
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista