Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells

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dc.contributor.authorUgarte, Giorgia D.
dc.contributor.authorVargas, Macarena F.
dc.contributor.authorMedina, Matías A.
dc.contributor.authorLeón, Pablo
dc.contributor.authorNecuñir, David
dc.contributor.authorElorza, Alvaro A.
dc.contributor.authorGutiérrez, Soraya E.
dc.contributor.authorMoon, Randall T.
dc.contributor.authorLoyola, Alejandra
dc.contributor.authorDe Ferrari, Giancarlo V.
dc.date.accessioned2023-03-06T15:04:44Z
dc.date.available2023-03-06T15:04:44Z
dc.date.issued2015-10
dc.descriptionIndexación: Scopuses
dc.description.abstractChromosomal translocations are frequently associated with a wide variety of cancers, particularly hematologic malignancies. A recurrent chromosomal abnormality in acute myeloid leukemia is the reciprocal translocation t(8;21) that fuses RUNX1 and ETO genes. We report here that Wnt/β-catenin signaling increases the expression of ETO and RUNX1 genes in human hematopoietic progenitors. We found that β-catenin is rapidly recruited into RNA polymerase II transcription factories (RNAPII-Ser5) and that ETO and RUNX1 genes are brought into close spatial proximity upon Wnt3a induction. Notably, long-term treatment of cells with Wnt3a induces the generation a frequent RUNX1-ETO translocation event. Thus, Wnt/β-catenin signaling induces transcription and translocation of RUNX1 and ETO fusion gene partners, opening a novel window to understand the onset/development of leukemia. © 2015 by The American Society of Hematology.es
dc.description.urihttps://ashpublications.org/blood/article/126/15/1785/34663/Wnt-signaling-induces-transcription-spatial
dc.identifier.doi10.1182/blood-2015-04-638494
dc.identifier.issn0006-4971
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/47344
dc.language.isoenes
dc.publisherAmerican Society of Hematologyes
dc.relation.urihttps://ashpublications.org/blood/article/126/15/1785/34663/Wnt-signaling-induces-transcription-spatial
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectMutationes
dc.subjectAcute Myeloid Leukemiaes
dc.subjectTranscription Factor RUNX1es
dc.titleWnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cellses
dc.typeArtículoes
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Blood Volume 126, Issue 15, Pages 1785 - 17898 October 2015
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