Persistent Salmonella enterica serovar Typhimurium infection increases the susceptibility of mice to develop intestinal inflammation

Vista sencilla de ítem
dc.contributor.authorSchultz, B.M.
dc.contributor.authorSalazar, G.A.
dc.contributor.authorPaduro, C.A.
dc.contributor.authorPardo-Roa, C.
dc.contributor.authorPizarro, D.P.
dc.contributor.authorSalazar-Echegarai, F.J.
dc.contributor.authorTorres, J.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorKalergis, A.M.
dc.contributor.authorAlvarez-Lobos, M.M.
dc.contributor.authorBueno, S.M.
dc.date.accessioned2019-05-29T15:03:10Z
dc.date.available2019-05-29T15:03:10Z
dc.date.issued2018-05
dc.descriptionIndexación: Scopus.es_ES
dc.descriptionThis study was supported by grants 'Fondo Nacional de Ciencia y Tecnología de Chile' (FONDECYT) (# 1100971, 1110604, 1140010, 1150862, 1161525, 1131012, and 1170964); Millenium Institute on Immunology and Immunotherapy P09/016-F from the Iniciativa Científica Milenio, Ministry of Economy, Chilean Government; Proyecto Puente P 1715/2017, Dirección de Investigación, Vicerrectoría de Investigación, Pontificia Universidad Católica de Chile. BS and CP-R are supported by the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT).
dc.description.abstractChronic intestinal inflammations are triggered by genetic and environmental components. However, it remains unclear how specific changes in the microbiota, host immunity, or pathogen exposure could promote the onset and exacerbation of these diseases. Here, we evaluated whether Salmonella enterica serovar Typhimurium (S. Typhimurium) infection increases the susceptibility to develop intestinal inflammation in mice. Two mouse models were used to evaluate the impact of S. Typhimurium infection: the chemical induction of colitis by dextran sulfate sodium (DSS) and interleukin (IL)-10-/- mice, which develop spontaneous intestinal inflammation. We observed that S. Typhimurium infection makes DSS-treated and IL-10-/- mice more susceptible to develop intestinal inflammation. Importantly, this increased susceptibility is associated to the ability of S. Typhimurium to persist in liver and spleen of infected mice, which depends on the virulence proteins secreted by Salmonella Pathogenicity Island 2-encoded type three secretion system (TTSS-2). Although immunization with a live attenuated vaccine resulted in a moderate reduction of the IL-10-/- mice susceptibility to develop intestinal inflammation due to previous S. Typhimurium infection, it did not prevent bacterial persistence. Our results suggest that persistent S. Typhimurium infection may increase the susceptibility of mice to develop inflammation in the intestine, which could be associated with virulence proteins secreted by TTSS-2. © 2018 Schultz, Salazar, Paduro, Pardo-Roa, Pizarro, Salazar-Echegarai, Torres, Riedel, Kalergis, álvarez-Lobos and Bueno.es_ES
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01166/full
dc.identifier.citationFrontiers in Immunology, 9(MAY), art. no. 1166.es_ES
dc.identifier.issn1664-3224
dc.identifier.otherDOI: 10.3389/fimmu.2018.01166
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/8960
dc.language.isoenes_ES
dc.publisherFrontiers Mediaes_ES
dc.subjectColitises_ES
dc.subjectDextran sulfate sodiumes_ES
dc.subjectInflammatory bowel diseasees_ES
dc.subjectInterleukin-10es_ES
dc.subjectPersistencees_ES
dc.subjectSalmonella enterica serovares_ES
dc.subjectTyphimuriumes_ES
dc.titlePersistent Salmonella enterica serovar Typhimurium infection increases the susceptibility of mice to develop intestinal inflammationes_ES
dc.typeArtículoes_ES
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Schultz_B_Persistent_Salmonella_enterica.pdf
Tamaño:
4.19 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista