Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival

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dc.contributor.authorVallejos, Alejandro
dc.contributor.authorOlivares, Pedro
dc.contributor.authorVarela, Diego
dc.contributor.authorEcheverria, Cesar
dc.contributor.authorCabello Verrugio, Claudio
dc.contributor.authorPérez Leighton, Claudio
dc.contributor.authorSimon, Felipe
dc.date.accessioned2022-04-29T18:23:07Z
dc.date.available2022-04-29T18:23:07Z
dc.date.issued2018-12
dc.descriptionIndexación: Scopuses
dc.description.abstractSepsis syndrome is the most important cause of mortality in critically ill patients admitted to intensive care units (ICUs). However, current therapies for its prevention and treatment are still unsatisfactory, and the mortality rate is still high. Non-septic ICU patients are vulnerable to acquire sepsis syndrome. Thus, a preventive treatment for this population is needed. During sepsis syndrome and endotoxemia, severe hypotension, tachycardia, oxidative and immune response increase, multiple organ dysfunction syndrome (MODS) and decreased survival are observed. Leptin administration protects against negative effects of sepsis syndrome and endotoxemia. Furthermore, it is has been reported that leptin elevates blood pressure mediated by sympathetic nervous system activation. However, whether leptin administration before sepsis induction mediates its protective effects during sepsis through blood pressure regulation is not known. Therefore, we investigated whether pre-treatment of leptin improves blood pressure and MODS, resulting in survival increase during endotoxemia. The results showed that leptin administration before endotoxemia induction reduced both the hypotension and tachycardia characteristically observed during endotoxemia. Notably, this protective effect was observed early and late in the course of endotoxemia. Endotoxemia-induced MODS decreased in leptin-treated rats, which was reflected in normal values for liver and kidney function, inhibition of muscle mass wasting and maintenance of glycemia. Furthermore, leptin pre-treatment decreased the oxidative stress burst in blood and blunted the increased pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 observed during endotoxemia. Remarkably, according to the leptin-induced increase in survival, leptin pre-administration decreased the risk for death associated with sepsis syndrome at early and late times after endotoxemia induction. These results show a potential preventive therapy against sepsis syndrome and endotoxemia in vulnerable patients, based in the beneficial actions of leptin. © Copyright © 2018 Vallejos, Olivares, Varela, Echeverria, Cabello-Verrugio, Pérez-Leighton and Simon.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphys.2018.01800/full
dc.identifier.citationFrontiers in Physiology Volume 912 December 2018 Article number 1800es
dc.identifier.doi10.3389/fphys.2018.01800
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22424
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectEndotoxemiaes
dc.subjectHypotensiones
dc.subjectLeptines
dc.subjectMODSes
dc.subjectSepsises
dc.subjectSurvivales
dc.titlePreventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survivales
dc.typeArtículoes
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