Heme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infection

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dc.contributor.authorTognarelli, Eduardo I.
dc.contributor.authorDuarte, Luisa F.
dc.contributor.authorFarías, Mónica A.
dc.contributor.authorCancino, Felipe A.
dc.contributor.authorCorrales, Nicolás
dc.contributor.authorIbáñez, Francisco J.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorGonzález, Pablo A.
dc.date.accessioned2023-09-01T20:30:50Z
dc.date.available2023-09-01T20:30:50Z
dc.date.issued2023-05
dc.descriptionIndexación: Scopuses
dc.description.abstractHerpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections are highly prevalent in the human population and produce mild to life-threatening diseases. These viruses interfere with the function and viability of dendritic cells (DCs), which are professional antigen-presenting cells that initiate and regulate the host’s antiviral immune responses. Heme oxygenase-1 (HO-1) is an inducible host enzyme with reported antiviral activity against HSVs in epithelial cells and neurons. Here, we sought to assess whether HO-1 modulates the function and viability of DCs upon infection with HSV-1 or HSV-2. We found that the stimulation of HO-1 expression in HSV-inoculated DCs significantly recovered the viability of these cells and hampered viral egress. Furthermore, HSV-infected DCs stimulated to express HO-1 promoted the expression of anti-inflammatory molecules, such as PDL-1 and IL-10, and the activation of virus-specific CD4+ T cells with regulatory (Treg), Th17 and Treg/Th17 phenotypes. Moreover, HSV-infected DCs stimulated to express HO-1 and then transferred into mice, promoted the activation of virus-specific T cells and improved the outcome of HSV-1 skin infection. These findings suggest that stimulation of HO-1 expression in DCs limits the deleterious effects of HSVs over these cells and induces a favorable virus-specific immune response in the skin against HSV-1. © 2023 by the authors.es
dc.description.urihttps://www.mdpi.com/2076-3921/12/6/1170
dc.identifier.citationAntioxidants Volume 12, Issue 6May 2023 Article number 1170es
dc.identifier.doi10.3390/antiox12061170
dc.identifier.issn2076-3921
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52985
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAdaptive responsees
dc.subjectAntiviral druges
dc.subjectDendritic cellses
dc.subjectHeme oxygenase-1es
dc.subjectHerpes simplex viruses
dc.subjectSkin infectiones
dc.subjectTh17es
dc.subjectTreges
dc.subjectTreg/Th17es
dc.titleHeme Oxygenase-1 Expression in Dendritic Cells Contributes to Protective Immunity against Herpes Simplex Virus Skin Infectiones
dc.typeArtículoes
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