Assessment of changes in the oral microbiome that occur in dogs with periodontal disease

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dc.contributor.authorSantibáñez, Rodrigo
dc.contributor.authorRodríguez-Salas, Camila
dc.contributor.authorFlores-Yáñez, Carla
dc.contributor.authorGarrido, Daniel
dc.contributor.authorThomson, Pamela
dc.date.accessioned2025-02-17T16:14:23Z
dc.date.available2025-02-17T16:14:23Z
dc.date.issued2021-12
dc.descriptionIndexación: Scopus.
dc.description.abstractThe oral microbiome in dogs is a complex community. Under some circumstances, it contributes to periodontal disease, a prevalent inflammatory disease characterized by a complex interaction between oral microbes and the immune system. Porphyromonas and Tannerella spp. are usually dominant in this disease. How the oral microbiome community is altered in periodontal disease, especially sub-dominant microbial populations is unclear. Moreover, how microbiome functions are altered in this disease has not been studied. In this study, we compared the composition and the predicted functions of the microbiome of the cavity of healthy dogs to those with from periodontal disease. The microbiome of both groups clustered separately, indicating important differences. Periodontal disease resulted in a significant increase in Bacteroidetes and reductions in Actinobacteria and Proteobacteria. Porphyromonas abundance increased 2.7 times in periodontal disease, accompanied by increases in Bacteroides and Fusobacterium. It was predicted that aerobic respiratory processes are decreased in periodontal disease. Enrichment in fermentative processes and anaerobic glycolysis were suggestive of an anaerobic environment, also characterized by higher lipopolysaccharide biosynthesis. This study contributes to a better understanding of how periodontal disease modifies the oral microbiome and makes a prediction of the metabolic pathways that contribute to the inflammatory process observed in periodontal disease. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.urihttps://www.mdpi.com/2306-7381/8/12/291
dc.identifier.citationVeterinary Sciences, Volume 8, Issue 12, December 2021, Article number 291
dc.identifier.doi10.3390/vetsci8120291
dc.identifier.issn2306-7381
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63530
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject16S rRNA
dc.subjectOral microbiome
dc.subjectPeriodontal disease
dc.subjectPorphyromonas
dc.titleAssessment of changes in the oral microbiome that occur in dogs with periodontal disease
dc.typeArtículo
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