Extracellular cysteine in connexins: Role as redox sensors

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dc.contributor.authorRetamal, M.A.
dc.contributor.authorGarcía, I.E.
dc.contributor.authorPinto, B.I.
dc.contributor.authorPupo, A.
dc.contributor.authorBáez, D.
dc.contributor.authorStehberg, J.
dc.contributor.authorDel Rio, R.
dc.contributor.authorGonzález, C.
dc.date.accessioned2017-08-23T13:12:51Z
dc.date.available2017-08-23T13:12:51Z
dc.date.issued2016-01
dc.descriptionIndexación: Scopus.es_CL
dc.description.abstractConnexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression.es_CL
dc.description.urihttp://journal.frontiersin.org/article/10.3389/fphys.2016.00001/full
dc.identifier.citationFrontiers in Physiology. Volume 7, Issue January 28, 2016, Article number 1es_CL
dc.identifier.issn1664-042X
dc.identifier.otherhttps://doi.org/10.3389/fphys.2016.00001
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/3999
dc.language.isoenes_CL
dc.publisherFRONTIERS MEDIAes_CL
dc.subjectConnexinses_CL
dc.subjectGap junction channelses_CL
dc.subjectGaseous transmitterses_CL
dc.subjectHemichannelses_CL
dc.subjectPost-translational modificationes_CL
dc.subjectRedox potentiales_CL
dc.titleExtracellular cysteine in connexins: Role as redox sensorses_CL
dc.typeArtículoes_CL
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