Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers

Vista sencilla de ítem
dc.contributor.authorAbrigo, Johanna
dc.contributor.authorOlguín, Hugo
dc.contributor.authorGutierrez, Danae
dc.contributor.authorTacchi, Franco
dc.contributor.authorArrese, Marco
dc.contributor.authorCabrera, Daniel
dc.contributor.authorValero Breton, Mayalen
dc.contributor.authorElorza, Alvaro A.
dc.contributor.authorSimon, Felipe
dc.contributor.authorCabello Verrugio, Claudio
dc.date.accessioned2023-08-28T16:58:14Z
dc.date.available2023-08-28T16:58:14Z
dc.date.issued2022-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractCholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a skeletal muscle disorder with the hallmarks of muscle weakness, muscle mass loss, and muscle strength decline. Our previous report demonstrated that deoxycholic acid (DCA) and cholic acid (CA), through the membrane receptor TGR5, induce a sarcopenia-like phenotype in myotubes and muscle fibers. The present study aimed to evaluate the impact of DCA and CA on mitochondrial mass and function in muscle fibers and the role of the TGR5 receptor. To this end, muscle fibers obtained from wild-type and TGR5−/− mice were incubated with DCA and CA. Our results indicated that DCA and CA decreased mitochondrial mass, DNA, and potential in a TGR5-dependent fashion. Furthermore, with TGR5 participation, DCA and CA also reduced the oxygen consumption rate and complexes I and II from the mitochondrial electron transport chain. In addition, DCA and CA generated more mitochondrial reactive oxygen species than the control, which were abolished in TGR5−/− mice muscle fibers. Our results indicate that DCA and CA induce mitochondrial dysfunction in muscle fibers through a TGR5-dependent mechanism. © 2022 by the authors.es
dc.description.urihttps://www.mdpi.com/2076-3921/11/9/1706
dc.identifier.citationAntioxidants, Volume 11, Issue 9, September 2022, Article number 1706es
dc.identifier.doi10.3390/antiox11091706
dc.identifier.issn2076-3921
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52868
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBile acidses
dc.subjectMitochondriaes
dc.subjectMuscle wastinges
dc.subjectSarcopeniaes
dc.subjectTGR5 receptores
dc.titleBile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fiberses
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Abrigo_Bile_acids_induce_alterations_in.pdf
Tamaño:
1.63 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista