Retrospective evaluation of deep transcranial magnetic stimulation as add-on treatment for Parkinson's disease

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dc.contributor.authorTorres, Francisco
dc.contributor.authorVillalon, Esteban
dc.contributor.authorPoblete, Patricio
dc.contributor.authorMoraga-Amaro, Rodrigo
dc.contributor.authorLinsambarth, Sergio
dc.contributor.authorRiquelme, Raúl
dc.contributor.authorZangen, Abraham
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2023-07-20T14:52:40Z
dc.date.available2023-07-20T14:52:40Z
dc.date.issued2015-10
dc.descriptionIndexación: Scopuses
dc.description.abstractObjective: To evaluate the safety and assess the different symptom improvements found after a combined low-frequency primary motor cortex and high-frequency prefrontal cortex (PFC) stimulation using the deep TMS (dTMS) H-coil, as an add-on treatment for Parkinson's disease (PD). Methods: Forty-five PD patients underwent 14 dTMS sessions; each consisting of 1 Hz stimulation of the primary motor cortex for 15 min, followed by 10 Hz stimulation of the PFC for 15 min. Clinical assessments were performed, BEFORE, at the MIDDLE, and END of therapy as well as at FOLLOW-UP after 30 days, using Movement Disorder Society-Unified Parkinson's Disease Rating Scale, TINETTI, UP&GO, SCOPA, HDRS 21, Beck Depression Inventory, and self-applied daily motor assessment scales. Results: Treatment was well-tolerated, without serious adverse effects. dTMS-induced significant PD symptom improvements at END and at FOLLOW-UP, in all subscales of the UPDRS, gait speed, depressive symptoms, balance, autonomic symptoms, and a 73% increase in daily ON time. Conclusion: In the cohort of PD patients treated, dTMS was well-tolerated with only minor adverse effects. The dTMS-induced significant improvements in motor, postural, and motivational symptoms of PD patients and may potentiate concurrent levodopa treatment. Significance: The present study demonstrates that dTMS may have a much wider spectrum of beneficial effects than previously reported for TMS, including enhancement of levodopa effects, suggesting that future clinical trials with dTMS should include a broader range of symptom measurements. © 2015 Torres, Villalon, Poblete, Moraga-Amaro, Linsambarth, Riquelme, Zangen and Stehberg.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fneur.2015.00210/full
dc.identifier.citationFrontiers in Neurology Volume 6, Issue OCT2015 Article number 210es
dc.identifier.doi10.3389/fneur.2015.00210
dc.identifier.issn1664-2295
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51839
dc.language.isoenes
dc.publisherFrontiers Research Foundationes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectDeep TMSes
dc.subjectH-coiles
dc.subjectHigh and low frequencyes
dc.subjectMotor cortexes
dc.subjectParkinson's diseasees
dc.subjectPrefrontal cortexes
dc.subjectRepetitive transcranial magnetic stimulationes
dc.titleRetrospective evaluation of deep transcranial magnetic stimulation as add-on treatment for Parkinson's diseasees
dc.typeArtículoes
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