Successful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19

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dc.contributor.authorCruces, P.
dc.contributor.authorCores, C.
dc.contributor.authorCasanova, D.
dc.contributor.authorPizarro, F.
dc.contributor.authorDíaz, F.
dc.date.accessioned2021-05-13T22:36:32Z
dc.date.available2021-05-13T22:36:32Z
dc.date.issued2021-06
dc.descriptionIndexación Scopuses
dc.description.abstractBackground: COVID-19 is a disease associated with an intense systemic inflammation that could induce severe acute respiratory distress syndrome (ARDS), with life-threatening hypoxia and hypercapnia. We present a case where mild therapeutic hypothermia was associated with improved gas exchange, facing other therapies' unavailability due to the pandemic. Case report: A healthy 38-year-old male admitted for COVID-19 pneumonia developed extreme hypoxia (PaO2/FiO2 ratio 42 mmHg), respiratory acidosis, and hyperthermia, refractory to usual treatment (mechanical ventilation, neuromuscular blockade, and prone position), and advanced therapies were not available. Mild therapeutic hypothermia management (target 33–34 °C) was maintained for five days, with progressive gas exchange improvement, which allowed his recovery over the following weeks. He was discharged home after 68 days without significant ICU associated morbidity. Conclusions: Mild hypothermia is a widely available therapy, that given some specific characteristics of COVID-19, may be explored as adjunctive therapy for life-threatening ARDS, especially during a shortage of other rescue therapies. © 2021 Elsevier Inc.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0883944121000095?via%3Dihub
dc.identifier.citationJournal of Critical Care, Volume 63, June 2021, Pages 260-263es
dc.identifier.doi10.1016/j.jcrc.2021.01.008
dc.identifier.issn08839441
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/18851
dc.language.isoenes
dc.publisherW.B. Saunderses
dc.subjectHypothermiaes
dc.subjectAdult Respiratory Distress Syndromees
dc.subjectAcute Lung Injuryes
dc.subjectCOVID-19es
dc.titleSuccessful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19es
dc.typeArtículoes
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