Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma
dc.contributor.author | Shibata, Ryohei | |
dc.contributor.author | Zhu, Zhaozhong | |
dc.contributor.author | Ooka, Tadao | |
dc.contributor.author | Freishtat, Robert J. | |
dc.contributor.author | Mansbach, Jonathan M. | |
dc.contributor.author | Pérez-Losada, Marcos | |
dc.contributor.author | Ramos-Tapia, Ignacio | |
dc.contributor.author | Teach, Stephen | |
dc.contributor.author | Camargo, Carlos A. | |
dc.contributor.author | Hasegawa, Kohei | |
dc.date.accessioned | 2024-04-05T15:47:22Z | |
dc.date.available | 2024-04-05T15:47:22Z | |
dc.date.issued | 2023 | |
dc.description | Indexación: Scopus | |
dc.description.abstract | Background: Bronchiolitis is the leading cause of infant hospitalization in U.S. and is associated with increased risk for childhood asthma. Immunoglobulin E (IgE) not only plays major roles in antiviral immune responses and atopic predisposition, but also offers a potential therapeutic target. Objective: We aimed to identify phenotypes of infant bronchiolitis by using total IgE (tIgE) and virus data, to determine their association with asthma development, and examine their biological characteristics. Methods: In a multicenter prospective cohort study of 1,016 infants (age <1 year) hospitalized for bronchiolitis, we applied clustering approaches to identify phenotypes by integrating tIgE and virus (respiratory syncytial virus [RSV], rhinovirus [RV]) data at hospitalization. We examined their longitudinal association with the risk of developing asthma by age 6 years and investigated their biological characteristics by integrating the upper airway mRNA and microRNA data in a subset (n=182). Results: In infants hospitalized for bronchiolitis, we identified 4 phenotypes: 1) tIgElowvirusRSV-high, 2) tIgElowvirusRSV-low/RV, 3) tIgEhighvirusRSV-high, and 4) tIgEhighvirusRSV-low/RV phenotypes. Compared to phenotype 1 infants (resembling “classic” bronchiolitis), phenotype 4 infants (tIgEhighvirusRSV-low/RV) had a significantly higher risk for developing asthma (19% vs. 43%; adjOR, 2.93; 95% CI, 1.02–8.43; P=.046). Phenotypes 3 and 4 (tIgEhigh) had depleted type I interferon and enriched antigen presentation pathways; phenotype 4 also had depleted airway epithelium structure pathways. Conclusions: In this multicenter cohort, tIgE-virus clustering identified distinct phenotypes of infant bronchiolitis with differential risks of asthma development and unique biological characteristics. Copyright © 2023 Shibata, Zhu, Ooka, Freishtat, Mansbach, Pérez-Losada, Ramos-Tapia, Teach, Camargo and Hasegawa. | |
dc.description.uri | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1187065/full | |
dc.identifier.citation | Frontiers in Immunology. Volume 14. 2023. Article number 1187065 | |
dc.identifier.doi | 10.3389/fimmu.2023.1187065 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | https://repositorio.unab.cl/handle/ria/55690 | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.rights.license | CC BY 4.0 DEED Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Asthma | |
dc.subject | Bronchiolitis | |
dc.subject | Immunoglobulin E | |
dc.subject | MicroRNA | |
dc.subject | mRNA | |
dc.subject | Phenotyping | |
dc.subject | Rhinovirus (RV) | |
dc.subject | RSV (respiratory syncytial virus) | |
dc.title | Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma | |
dc.type | Artículo |
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