Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection

Vista sencilla de ítem
dc.contributor.authorMoore, Carolina
dc.contributor.authorTejon, Gabriela
dc.contributor.authorFuentes, Camila
dc.contributor.authorHidalgo, Yessia
dc.contributor.authorBono, Maria R.
dc.contributor.authorMaldonado, Paula
dc.contributor.authorFernandez, Ricardo
dc.contributor.authorWood, Kathryn J.
dc.contributor.authorFierro, Juan A.
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorSauma, Daniela
dc.contributor.authorBushell, Andrew
dc.date.accessioned2023-07-17T16:14:30Z
dc.date.available2023-07-17T16:14:30Z
dc.date.issued2015-02
dc.descriptionIndexación: Scopuses
dc.description.abstractCD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation of Treg cells in the presence of TGF-β. In this study, we show that the co-culture of naive T cells from C57BL/6 mice with allogeneic antigen-presenting cells (APCs) from BALB/c mice in the presence of TGF-β, RA, and IL-2 resulted in a striking enrichment of Foxp3+ T cells. These RA in vitro-induced regulatory T (RA-iTreg) cells did not secrete Th1-, Th2-, or Th17-related cytokines, showed a nonbiased homing potential, and expressed several cell surface molecules related to Treg-cell suppressive potential. Accordingly, these RA-iTreg cells suppressed T-cell proliferation and inhibited cytokine production by T cells in in vitro assays. Moreover, following adoptive transfer, RA-iTreg cells maintained Foxp3 expression and their suppressive capacity. Finally, RA-iTreg cells showed alloantigen-specific immunosuppressive capacity in a skin allograft model in immunodeficient mice. Altogether, these data indicate that functional and stable allogeneic-specific Treg cells may be generated using TGF-β, RA, and IL-2. Thus, RA-iTreg cells may have a potential use in the development of more effective cellular therapies in clinical transplantation. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.es
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1002/eji.201444743
dc.identifier.citationEuropean Journal of Immunology Volume 45, Issue 2, Pages 452 - 4631 February 2015es
dc.identifier.doi
dc.identifier.doi10.1002/eji.201444743
dc.identifier.issn0014-2980
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51692
dc.language.isoenes
dc.publisherWiley-VCH Verlages
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAllogeneic regulatory T cellses
dc.subjectHominges
dc.subjectRetinoic acides
dc.subjectTolerancees
dc.subjectTransplantationes
dc.titleAlloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejectiones
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Eur J Immunol - 2014 - Moore - Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft.pdf
Tamaño:
2.39 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista