Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

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dc.contributor.authorCisternas, Pedro
dc.contributor.authorSalazar, Paulina
dc.contributor.authorSerrano, Felipe G.
dc.contributor.authorMontecinos-Oliva, Carla
dc.contributor.authorArredondo, Sebastián B.
dc.contributor.authorVarela-Nallar, Lorena
dc.contributor.authorBarja, Salesa
dc.contributor.authorVio, Carlos P.
dc.contributor.authorGomez-Pinilla, Fernando
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2023-02-16T14:48:02Z
dc.date.available2023-02-16T14:48:02Z
dc.date.issued2015-11
dc.descriptionIndexación: Scopuses
dc.description.abstractMetabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has limited the development of therapeutic strategies. We induced a MetS-like condition by exposing mice to fructose feeding for 7. weeks. There was a dramatic deterioration in the capacity of the hippocampus to sustain synaptic plasticity in the forms of long-term potentiation (LTP) and long-term depression (LTD). Mice exposed to fructose showed a reduction in the number of contact zones and the size of postsynaptic densities (PSDs) in the hippocampus, as well as a decrease in hippocampal neurogenesis. There was an increase in lipid peroxidation likely associated with a deficiency in plasma membrane excitability. Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. Most of the pathological sequel of MetS in the brain was reversed three month after discontinue fructose feeding. These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. The overall information raises concerns about the risk imposed by excessive fructose consumption on the pathology of neurological disorders. © 2015.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0925443915002434?via%3Dihub
dc.identifier.doi10.1016/j.bbadis.2015.08.016
dc.identifier.issn0925-4439
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/46928
dc.language.isoenes
dc.publisherElsevieres
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCarpses
dc.subjectFish Meales
dc.subjectOncorhynchus Mykisses
dc.titleFructose consumption reduces hippocampal synaptic plasticity underlying cognitive performancees
dc.typeArtículoes
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Biochimica et Biophysica Acta - Molecular Basis of Disease Volume 1852, Issue 11, Pages 2379 - 2390November 01, 2015
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