Effect of Electrical Stimulation on PC12 Cells Cultured in Different Hydrogels: Basis for the Development of Biomaterials in Peripheral Nerve Tissue Engineering

Vista sencilla de ítem
dc.contributor.authorOlguín, Yusser
dc.contributor.authorSelva, Mónica
dc.contributor.authorBenavente, Diego
dc.contributor.authorOrellana, Nicole
dc.contributor.authorMontenegro, Ivan
dc.contributor.authorMadrid, Alejandro
dc.contributor.authorJaramillo-Pinto, Diego
dc.contributor.authorOtero, María Carolina
dc.contributor.authorCorrales, Tomas P.
dc.contributor.authorAcevedo, Cristian A.
dc.date.accessioned2024-03-11T20:14:09Z
dc.date.available2024-03-11T20:14:09Z
dc.date.issued2023-12
dc.descriptionIndexación: Scopus.
dc.description.abstractExtensive damage to peripheral nerves is a health problem with few therapeutic alternatives. In this context, the development of tissue engineering seeks to obtain materials that can help recreate environments conducive to cellular development and functional repair of peripheral nerves. Different hydrogels have been studied and presented as alternatives for future treatments to emulate the morphological characteristics of nerves. Along with this, other research proposes the need to incorporate electrical stimuli into treatments as agents that promote cell growth and differentiation; however, no precedent correlates the simultaneous effects of the types of hydrogel and electrical stimuli. This research evaluates the neural differentiation of PC12 cells, relating the effect of collagen, alginate, GelMA, and PEGDA hydrogels with electrical stimulation modulated in four different ways. Our results show significant correlations for different cultivation conditions. Electrical stimuli significantly increase neural differentiation for specific experimental conditions dependent on electrical frequency, not voltage. These backgrounds allow new material treatment schemes to be formulated through electrical stimulation in peripheral nerve tissue engineering. © 2023 by the authors.
dc.identifier.citationPharmaceutics. Volume 15, Issue 12. December 2023 Article number 2760
dc.identifier.doi10.3390/pharmaceutics15122760
dc.identifier.issn1999-4923
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55062
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectelectrical stimulation
dc.subjecthydrogels
dc.subjectPC12 cells
dc.subjectperipheral nerve tissue engineering
dc.titleEffect of Electrical Stimulation on PC12 Cells Cultured in Different Hydrogels: Basis for the Development of Biomaterials in Peripheral Nerve Tissue Engineering
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
pharmaceutics-15-02760-v2.pdf
Tamaño:
5.69 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista