A single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in rats

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dc.contributor.authorMoraga-Amaro, Rodrigo
dc.contributor.authorCyprien G. J
dc.contributor.authorReali Nazario, Luiza
dc.contributor.authorLima Giacobbo, Bruno
dc.contributor.authorJ. O. Dierckx, Rudi A
dc.contributor.authorStehberg, Jimmy
dc.contributor.authorde Vries, Erik F. J
dc.contributor.authorDoorduin, Janine
dc.date.accessioned2022-06-29T15:37:17Z
dc.date.available2022-06-29T15:37:17Z
dc.date.issued2022-04
dc.description.abstractWorldwide, millions of people suffer from treatment-resistant depression. Ketamine, a glutamatergic receptor antagonist, can have a rapid antidepressant effect even in treatment-resistant patients. A proposed mechanism for the antidepressant effect of ketamine is the reduction of neuroinflammation. To further explore this hypothesis, we investigated whether a single dose of ketamine can modulate protracted neuroinflammation in a repeated social defeat (RSD) stress rat model, which resembles features of depression. To this end, male animals exposed to RSD were injected with ketamine (20 mg/kg) or vehicle. A combination of behavioral analyses and PET scans of the inflammatory marker TSPO in the brain were performed. Rats submitted to RSD showed anhedonia-like behavior in the sucrose preference test, decreased weight gain, and increased TSPO levels in the insular and entorhinal cortices, as observed by [11C]-PK11195 PET. Whole brain TSPO levels correlated with corticosterone levels in several brain regions of RSD exposed animals, but not in controls. Ketamine injection 1 day after RSD disrupted the correlation between TSPO levels and serum corticosterone levels, but had no effect on depressive-like symptoms, weight gain or the protracted RSD-induced increase in TSPO expression in male rats. These results suggest that ketamine does not exert its effect on the hypothalamic–pituitary–adrenal axis by modulation of neuroinflammation. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.es
dc.description.sponsorshipIndexación: Scopuses
dc.identifier.citationStress Open Access Volume 25, Issue 1, Pages 145 - 1552022es
dc.identifier.issn10253890
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23059
dc.language.isoenes
dc.publisherTaylor and Francis Ltd.es
dc.subjectketamine; major depressive disorder; Neuroinflammation; positron emission tomography; repeated social defeates
dc.titleA single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in ratses
dc.typeArtículoes
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