Green by design: Convergent synthesis, computational analyses, and activity evaluation of new fxa inhibitors bearing peptide triazole linking units

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dc.contributor.authorRodríguez, Diego F.
dc.contributor.authorDurán-Osorio, Francisca
dc.contributor.authorDuarte, Yorley
dc.contributor.authorOlivares, Pedro
dc.contributor.authorMoglie, Yanina
dc.contributor.authorDua, Kamal
dc.contributor.authorZacconi, Flavia C.
dc.date.accessioned2022-07-20T20:14:14Z
dc.date.available2022-07-20T20:14:14Z
dc.date.issued2022-01
dc.descriptionIndexación Scopuses
dc.description.abstractGreen chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a considerable challenge. Herein, we wish to report a green synthesis of new pharmaceutically active peptide triazoles as potent factor Xa inhibitors, an important drug target associated with the treatment of diverse cardiovascular diseases. The new inhibitors were synthesized in three steps, featuring cycloaddition reactions (high atom economy), microwave-assisted organic synthesis (energy efficiency), and copper nanoparticle catalysis, thus featuring Earth-abundant metals. The molecules obtained showed FXa inhibition, with IC50-values as low as 17.2 μM and no associated cytotoxicity in HEK293 and HeLa cells. These results showcase the environmental potential and chemical implications of the applied methodologies for the development of new molecules with pharmacological potential.es
dc.identifier.citationPharmaceutics Volume 14, Issue 1 January 2022 Article number 33es
dc.identifier.doi10.3390/pharmaceutics14010033en
dc.identifier.issn1999-4923
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23290
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectClick chemistryes
dc.subjectDOACses
dc.subjectDrug discoveryes
dc.subjectFXa inhibitorses
dc.subjectGreen chemistryes
dc.subjectMicrowave synthesises
dc.subjectUllmann-Goldberg reactiones
dc.titleGreen by design: Convergent synthesis, computational analyses, and activity evaluation of new fxa inhibitors bearing peptide triazole linking unitses
dc.typeArtículoes
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