Differential metabolic and transcriptional responses of gilthead seabream (Sparus aurata) administered with cortisol or cortisol-BSA

Vista sencilla de ítem
dc.contributor.authorAedo, Jorge
dc.contributor.authorAravena-Canales, Daniela
dc.contributor.authorRuiz-Jarabo, Ignacio
dc.contributor.authorOyarzún, Ricardo
dc.contributor.authorMolina, Alfredo
dc.contributor.authorMartínez-Rodríguez, Gonzalo
dc.contributor.authorValdés, Juan Antonio
dc.contributor.authorMancera, Juan Miguel
dc.date.accessioned2025-03-18T22:38:18Z
dc.date.available2025-03-18T22:38:18Z
dc.date.issued2021-11
dc.descriptionIndexación: Scopus.
dc.description.abstractCortisol is the main glucocorticoid hormone promoting compensatory metabolic responses of stress in teleosts. This hormone acts through genomic and membrane-initiated actions to exert its functions inside the cell. Experimental approaches, using exogenous cortisol administration, confirm the role of this hormone during short (minutes to hours)-and long-term (days to weeks) responses to stress. The role of membrane-initiated cortisol signaling during long-term responses has been recently explored. In this study, Sparus aurata were intraperitoneally injected with coconut oil alone or coconut oil containing cortisol, cortisol-BSA, or BSA. After 3 days of treatment, plasma, liver, and skeletal muscle were extracted. Plasma cortisol, as well as metabolic indicators in the plasma and tissues collected, and metabolism-related gene expression, were measured. Our results showed that artificially increased plasma cortisol levels in S. aurata enhanced plasma glucose and triacylglycerols values as well as hepatic substrate energy mobilization. Additionally, cortisol stimulated hepatic carbohydrates metabolism, as seen by the increased expression of metabolism-related genes. All of these responses, observed in cortisol-administered fish, were not detected by replicating the same protocol and instead using cortisol-BSA, which exclusively induces membrane-initiated effects. Therefore, we suggest that after three days of cortisol administration, only genomic actions are involved in the metabolic responses in S. aurata. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.urihttps://www.mdpi.com/2076-2615/11/11/3310
dc.identifier.citationAnimals, Volume 11, Issue 11, November 2021, Article number 3310
dc.identifier.doi10.3390/ani11113310
dc.identifier.issn2076-2615
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63816
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCortisol
dc.subjectEnergetic metabolism
dc.subjectFish
dc.subjectGlucocorticoids
dc.subjectSparus aurata
dc.subjectStress response
dc.titleDifferential metabolic and transcriptional responses of gilthead seabream (Sparus aurata) administered with cortisol or cortisol-BSA
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Aedo_Differential_metabolic_and_transcriptional.pdf
Tamaño:
1.26 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista