From genes to systems: The role of food supplementation in the regulation of sepsis-induced inflammation
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Archivos
Fecha
2024-01
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier B.V.
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Systemic inflammation includes a widespread immune response to a harmful stimulus that results in extensive systemic damage. One common example of systemic inflammation is sepsis, which is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Under the pro-inflammatory environment of sepsis, oxidative stress contributes to tissue damage due to dysfunctional microcirculation that progressively causes the failure of multiple organs that ultimately triggers death. To address the underlying inflammatory condition in critically ill patients, progress has been made to assess the beneficial effects of dietary supplements, which include polyphenols, amino acids, fatty acids, vitamins, and minerals that are recognized for their immuno-modulating, anticoagulating, and analgesic properties. Therefore, we aimed to review and discuss the contribution of food-derived supplementation in the regulation of inflammation from gene expression to physiological responses and summarize the precedented potential of current therapeutic approaches during systemic inflammation. © 2023
Notas
Indexación: Scopus
Palabras clave
Amino Acids, Cytokines, Fatty Acids, Food Supplementation, Immune Cells, Minerals, Oxidative Stress, Polyphenols, Sepsis, Systemic Inflammation, Vitamins
Citación
Biochimica et Biophysica Acta - Molecular Basis of Disease. Open Access. Volume 1870, Issue . 1 January 2024. Article number 166909
DOI
10.1016/j.bbadis.2023.166909