Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development

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dc.contributor.authorUribe, Felipe R.
dc.contributor.authorGonzález, Valentina P. I.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorSoto, Jorge A.
dc.contributor.authorBohmwald, Karen
dc.date.accessioned2024-04-30T18:34:22Z
dc.date.available2024-04-30T18:34:22Z
dc.date.issued2024-01-01
dc.descriptionIndexación: Scopus.
dc.description.abstractCentral nervous system (CNS) pathologies are a public health concern, with viral infections one of their principal causes. These viruses are known as neurotropic pathogens, characterized by their ability to infiltrate the CNS and thus interact with various cell populations, inducing several diseases. The immune response elicited by neurotropic viruses in the CNS is commanded mainly by microglia, which, together with other local cells, can secrete inflammatory cytokines to fight the infection. The most relevant neurotropic viruses are adenovirus (AdV), cytomegalovirus (CMV), enterovirus (EV), Epstein–Barr Virus (EBV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2), lymphocytic choriomeningitis virus (LCMV), and the newly discovered SARS-CoV-2. Several studies have associated a viral infection with systemic lupus erythematosus (SLE) and neuropsychiatric lupus (NPSLE) manifestations. This article will review the knowledge about viral infections, CNS pathologies, and the immune response against them. Also, it allows us to understand the relevance of the different viral proteins in developing neuronal pathologies, SLE and NPSLE.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85183110190&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=7804409d450fc1afcddbb64ed6e195eb&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID(%22Universidad+Andr%C3%A9s+Bello%22+60002636)+AND+SUBJAREA(NEUR)&relpos=1&citeCnt=1&searchTerm=
dc.identifier.citationBrain Sciences Open Access Volume 14, Issue 1January 2024 Article number 59
dc.identifier.doi10.3390/brainsci14010059
dc.identifier.issn20763425
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56493
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectaseptic meningitis
dc.subjectcentral nervous system
dc.subjectencephalitis
dc.subjectimmune system
dc.subjectneurotropic viruses
dc.subjectsystemic lupus erythematosus
dc.titleUnderstanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development
dc.typeArtículo
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