High-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats

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dc.contributor.authorMercado-López, Lorena
dc.contributor.authorMuñoz, Yasna
dc.contributor.authorFarias, Camila
dc.contributor.authorBeyer, María Paz
dc.contributor.authorCarrasco-Gutiérrez, Robinson
dc.contributor.authorCaicedo-Paz, Angie Vanessa
dc.contributor.authorDagnino-Subiabre, Alexies
dc.contributor.authorEspinosa, Alejandra
dc.contributor.authorValenzuela, Rodrigo
dc.date.accessioned2025-04-22T17:46:46Z
dc.date.available2025-04-22T17:46:46Z
dc.date.issued0025
dc.descriptionINDEXACION SCOPUS
dc.description.abstractBackground/Objectives: This study investigates the effects of a high-fat diet (HFD) during pregnancy and lactation on maternal and offspring health, focusing on behavioral, metabolic, and fatty acid composition outcomes in a rat model. Methods: Twelve female Sprague–Dawley rats were fed either a control diet, CD (n = 6), or HFD (n = 6) for 12 weeks, encompassing mating, gestation, and lactation periods (18 weeks). Anxiety-like behavior, maternal behavior, depression-like behavior, and social play were studied. Post mortem, the liver function, hepatic steatosis, and fatty acid composition (erythrocytes, liver, adipose tissue) were evaluated. In regard to desaturase enzymes (Δ-6D and Δ-5D), liver activity, protein mass, and gene expression (RT-PCR) were analyzed. Additionally, gene expression of PPAR-α, ACOX, CPT1-α, SREBP-1c, ACC, and FAS was assessed. Statistical analysis was performed using Student’s t-test, mean ± SD (p < 0.05). Results: The HFD significantly increased maternal weight and anxiety-like behavior while reducing social interactions exclusively in male offspring (p < 0.05). It also led to a significant decrease in the synthesis and content of n-3 PUFAs in the analyzed tissues, induced hepatic steatosis, and upregulated the expression of pro-lipogenic genes in the maternal liver. Conclusions: These findings suggest that long-term HFD consumption alters tissue fatty acid composition, disrupts metabolic homeostasis, and contributes to behavioral changes, increasing anxiety-like behaviors in pregnant dams and reducing social interactions in male offspring. Overall, this study provides further insight into the detrimental effects of HFD consumption during the perinatal period. © 2025 by the authors.
dc.identifier.issn20726643
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/64249
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectalpha-linolenic acid; anxiety; docosahexaenoic acid; fatty acid metabolism; high-fat diet; linoleic acid; n-3 polyunsaturated fatty acid; pregnancy
dc.titleHigh-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats
dc.typeArtículo
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HighFat-Diet-in-Perinatal-Period-Promotes-Liver-Steatosis-and-Low-Desaturation-Capacity-of-Polyunsaturated-Fatty-Acids-in-Dams-A-Link-with-AnxietyLike-Behavior-in-RatsNutrients.pdf
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