Antigen-Presenting Cells and T Cells Interact in a Specific Area of the Intestinal Mucosa Defined by the Ccl25-Ccr9 Axis in Medaka

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dc.contributor.authorAghaallaei, Narges
dc.contributor.authorAgarwal, Rashi
dc.contributor.authorBenjaminsen, Joergen
dc.contributor.authorLust, Katharina
dc.contributor.authorBajoghli, Baubak
dc.contributor.authorWittbrodt, Joachim
dc.contributor.authorFeijoo, Carmen G.
dc.date.accessioned2022-06-17T17:07:27Z
dc.date.available2022-06-17T17:07:27Z
dc.date.issued2022-02
dc.descriptionIndexación :Scopuses
dc.description.abstractOrganized intestinal mucosal immune response appears to be restricted to tetrapods. In teleost fish, there is no evidence for the existence of a particular intestinal region that facilitates the interaction of antigen-presenting cells (APCs) and T cells, such as secondary lymphoid organs. Indeed, despite their importance in the defense against pathogens, the location and manner of APC-T cell interaction within the fish gut is unknown. Here, using non-invasive live imaging of newly developed transgenic reporter lines, we addressed the spatial organization and behavior of APCs and T cells in the intestine of medaka fish both during homeostasis and inflammation. We report that Ccr9a+ T cells are recruited to a band in the lamina propria next to the muscularis mucosa in which Ccl25-expressing cells are present. Ccr9a+ T cells contact APCs for several minutes, in a process mediated by connexin 43. This type of interaction was observed in homeostasis and inflammation, with the interaction being longer and more frequent during inflammation. Thus, our results demonstrate that the mucosal immune response in the intestine of medaka is organized and endowed with a specific region with specialized microenvironment and function. Copyright © 2022 Aghaallaei, Agarwal, Benjaminsen, Lust, Bajoghli, Wittbrodt and Feijoo.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2022.812899/full
dc.identifier.citationFrontiers in Immunology Volume 133 February 2022 Article number 812899es
dc.identifier.doi10.3389/fimmu.2022.812899
dc.identifier.issn16643224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22897
dc.language.isoeses
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAntigen-presenting celles
dc.subjectIntestinees
dc.subjectMucosal immune responsees
dc.subjectT cellses
dc.subjectTeleost fish modeles
dc.titleAntigen-Presenting Cells and T Cells Interact in a Specific Area of the Intestinal Mucosa Defined by the Ccl25-Ccr9 Axis in Medakaes
dc.typeArtículoes
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