Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infection

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dc.contributor.authorGonzález, Liliana A.
dc.contributor.authorMelo González, Felipe
dc.contributor.authorSebastián, Valentina P.
dc.contributor.authorVallejos, Omar P.
dc.contributor.authorNoguera, Loreani P.
dc.contributor.authorSuazo, Isidora D.
dc.contributor.authorSchultz, Bárbara M.
dc.contributor.authorManosalva, Andrés H.
dc.contributor.authorPeñaloza, Hernán F.
dc.contributor.authorSoto, Jorge A.
dc.contributor.authorParker, Dane
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2022-08-08T22:12:05Z
dc.date.available2022-08-08T22:12:05Z
dc.date.issued2021-04
dc.descriptionIndexación: Scopuses
dc.description.abstractNeutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung infection with Streptococcus pneumoniae in mice, interleukin-10 (IL-10) production is required to temper an excessive lung injury and to improve survival, yet the cellular source of IL-10 and the immunomodulatory role of neutrophils during S. pneumoniae infection remain unknown. Here we show that neutrophils are the main myeloid cells that produce IL-10 in the lungs during the first 48 h of infection. Importantly, in vitro assays with bone-marrow derived neutrophils confirmed that IL-10 can be induced by these cells by the direct recognition of pneumococcal antigens. In vivo, we identified the recruitment of two neutrophil subpopulations in the lungs following infection, which exhibited clear morphological differences and a distinctive profile of IL-10 production at 48 h post-infection. Furthermore, adoptive transfer of neutrophils from WT mice into IL-10 knockout mice (Il10-/-) fully restored IL-10 production in the lungs and reduced lung histopathology. These results suggest that IL-10 production by neutrophils induced by S. pneumoniae limits lung injury and is important to mediate an effective immune response required for host survival. © Copyright © 2021 González, Melo-González, Sebastián, Vallejos, Noguera, Suazo, Schultz, Manosalva, Peñaloza, Soto, Parker, Riedel, González, Kalergis and Bueno.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2021.638917/full
dc.identifier.citationFrontiers in Immunology Volume 1228 April 2021 Article number 638917es
dc.identifier.doi10.3389/fimmu.2021.638917
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23501
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAdoptive neutrophil transferes
dc.subjectIL-10-producing neutrophilses
dc.subjectInterleukin-10es
dc.subjectPneumoniaes
dc.subjectStreptococcus pneumoniaees
dc.titleCharacterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infectiones
dc.typeArtículoes
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