Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives

Vista sencilla de ítem
dc.contributor.authorOlivero, Pablo
dc.contributor.authorLozano, Carlo
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.authorMeza-Concha, Nicolás
dc.contributor.authorArancibia, Marcelo
dc.contributor.authorCórdova, Claudio
dc.contributor.authorGonzález-Arriagada, Wilfredo
dc.contributor.authorRamírez-Barrantes, Ricardo
dc.contributor.authorMarchant, Ivanny
dc.date.accessioned2022-09-09T15:34:18Z
dc.date.available2022-09-09T15:34:18Z
dc.date.issued2018
dc.descriptionIndexación Scopuses
dc.description.abstractProteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with several neuropsychiatric conditions. It has been observed that impaired mitochondrial function due to a dysregulated proteostasis control system, that is, ubiquitin-proteasome system and chaperones, could also have effects on neurodegenerative disorders. We aimed to critically analyze the available findings regarding the neurobiological implications of proteostasis on the development of neurodegenerative and psychiatric diseases, considering the mitochondrial role. Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins. Altered mitochondrial dynamics, especially in proteostasis processes, could impede the normal compensatory mechanisms against cell damage. Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background. It is expected that with the increasing evidence about proteostasis in neuropsychiatric disorders, new therapeutic alternatives will emerge. © 2018 Pablo Olivero et al.es
dc.description.urihttps://www.hindawi.com/journals/np/2018/6798712/
dc.identifier.citationNeural Plasticity Volume 2018, 2018 Article number 6798712es
dc.identifier.doi10.1155/2018/6798712
dc.identifier.issn20905904
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23822
dc.language.isoenes
dc.publisherHindawi Limitedes
dc.rights.licenseCC BY 4.0
dc.subjectAutophagyes
dc.subjectAmyloid Beta Proteines
dc.subjectSynucleinses
dc.titleProteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectiveses
dc.title.alternativeProteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectiveses
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Olivero_P_Proteosasis_2018.pdf
Tamaño:
1.43 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO ESPAÑOL
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista