The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

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dc.contributor.authorBarriga, E.
dc.contributor.authorMaxwell, P.
dc.contributor.authorReyes, A.
dc.contributor.authorMayor, R.
dc.date.accessioned2023-04-28T17:52:55Z
dc.date.available2023-04-28T17:52:55Z
dc.date.issued2013-05
dc.descriptionIndexación: Scopus.
dc.description.abstractOne of the most important mechanisms that promotes metastasis is the stabilization of Hif-1 (hypoxia-inducible transcription factor 1). We decided to test whether Hif-1α also was required for early embryonic development. We focused our attention on the development of the neural crest, a highly migratory embryonic cell population whose behavior has been likened to cancer metastasis. Inhibition of Hif-1α by antisense morpholinos in Xenopus laevis or zebrafish embryos led to complete inhibition of neural crest migration. We show that Hif-1α controls the expression of Twist, which in turn represses E-cadherin during epithelial to mesenchymal transition (EMT) of neural crest cells. Thus, Hif-1α allows cells to initiate migration by promoting the release of cell- cell adhesions. Additionally, Hif-1α controls chemotaxis toward the chemokine SDF-1 by regulating expression of its receptor Cxcr4. Our results point to Hif-1α as a novel and key regulator that integrates EMT and chemotaxis during migration of neural crest cells.es
dc.description.urihttps://rupress.org/jcb/article/201/5/759/37304/The-hypoxia-factor-Hif-1-controls-neural-crest
dc.identifier.citationJournal of Cell Biology, Volume 201, Issue 5, Pages 759 - 776, May 2013es
dc.identifier.doi10.1083/jcb.201212100
dc.identifier.issn1540-8140
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49127
dc.language.isoenes
dc.publisherRockefeller University Presses
dc.rights.licenseAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
dc.rights.urihttps://rupress.org/pages/permissions-and-licensing
dc.subjectNeural Crestes
dc.subjectNeuroectodermes
dc.subjectAnimalses
dc.titleThe hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transitiones
dc.typeArtículoes
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