Unfolded protein stress in the endoplasmic reticulum and mitochondria: A role in neurodegeneration

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dc.contributor.authorBermales, S.
dc.contributor.authorSoto, M.
dc.contributor.authorMcCullagh, E.
dc.date.accessioned2023-06-23T19:24:21Z
dc.date.available2023-06-23T19:24:21Z
dc.date.issued2012
dc.descriptionIndexación: Scopus.es
dc.description.abstractProtein-folding occurs in several intracellular locations including the endoplasmic reticulum and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery. Disruption of homeostasis and an accumulation of unfolded proteins trigger stress responses, or unfolded protein responses (UPR), in these organelles. These pathways signal to increase the folding capacity, inhibit protein import or expression, increase protein degradation, and potentially trigger cell death. Many aging-related neurodegenerative diseases involve the accumulation of misfolded proteins in both the endoplasmic reticulum and mitochondria. The exact participation of the UPRs in the onset of neurodegeneration is unclear, but there is significant evidence for the alteration of these pathways in the endoplasmic reticulum and mitochondria. Here we will discuss the involvement of endoplasmic reticulum and mitochondrial stress and the possible contributions of the UPR in these organelles to the development of two neurodegenerative diseases, Parkinson's disease (PD) and Alzheimer's disease (AD).es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnagi.2012.00005/full
dc.identifier.citationFrontiers in Aging Neuroscience, Volume 4, Issue APR, Pages 1 - 13, 2012es
dc.identifier.doi10.3389/fnagi.2012.00005
dc.identifier.issn1663-4365
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51043
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAttribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
dc.subjectAlzheimer's diseasees
dc.subjectEndoplasmic reticulumes
dc.subjectMitochondriaes
dc.subjectNeurodegenerationes
dc.subjectParkinson's diseasees
dc.subjectUnfolded protein responsees
dc.titleUnfolded protein stress in the endoplasmic reticulum and mitochondria: A role in neurodegenerationes
dc.typeArtículoes
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