Farmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cáncer

Vista sencilla de ítem
dc.contributor.authorRoco, Á.
dc.contributor.authorCerda, B.
dc.contributor.authorCayún, J.P.
dc.contributor.authorLavanderos, A.
dc.contributor.authorRubilar, J.C.
dc.contributor.authorCerro, R.
dc.contributor.authorAcevedo, C.
dc.contributor.authorCáceres, D.
dc.contributor.authorVarela, N.
dc.contributor.authorQuiñones, L.A.
dc.date.accessioned2019-12-05T15:15:32Z
dc.date.available2019-12-05T15:15:32Z
dc.date.issued2018-08
dc.descriptionIndexación: Scopus; Scielo.es
dc.description.abstractCancer is the second leading cause of death in the world, causing 8.8 million deaths in 2015 according to the World Health Organization (WHO). Risk factors for cancer include smoking and alcohol consumption. In Chile, 33.6% of the population and 21.2% of young people smokes. Alcohol consumption in the Chilean population is 74.5% and 12.2% in young people. Among the physiological factors that influence the development of cancer, the genetic factor plays a relevant role. It has been shown that the presence of genetic polymorphisms that alter the ability of the body to eliminate contaminants increase the risk of developing cancer. The same applies to polymorphisms that prevent DNA repair due to damage caused by environmental pollutants such as cigarette smoke. The objective of this review is to analyze the state of the art of the relationship between pharmacogenetics, smoking, and alcohol consumption as risk factors for the development of cancer. In conclusion, the results suggest that the presence of polymorphisms that alter the function of biotransformation enzymes phase I (CYP1A1, CYP1E1) and phase II (GST), as well as polymorphisms in DNA repair enzymes (ERCC1 / ERCC2), increase the risk of cancer induced by smoking and alcohol consumption. This association is important considering that smoking and drinking alcohol are highly prevalent among the Chilean population. © 2018, Sociedad Chilena de Pediatria. All rights reserved.es
dc.description.abstractCancer is the second leading cause of death in the world, causing 8.8 million deaths in 2015 according to the World Health Organization (WHO). Risk factors for cancer include smoking and alcohol con sumption. In Chile, 33.6% of the population and 21.2% of young people smokes. Alcohol consump tion in the Chilean population is 74.5% and 12.2% in young people. Among the physiological factors that influence the development of cancer, the genetic factor plays a relevant role. It has been shown that the presence of genetic polymorphisms that alter the ability of the body to eliminate contami nants increase the risk of developing cancer. The same applies to polymorphisms that prevent DNA repair due to damage caused by environmental pollutants such as cigarette smoke. The objective of this review is to analyze the state of the art of the relationship between pharmacogenetics, smoking, and alcohol consumption as risk factors for the development of cancer. In conclusion, the results suggest that the presence of polymorphisms that alter the function of biotransformation enzymes phase I (CYP1A1, CYP1E1) and phase II (GST), as well as polymorphisms in DNA repair enzymes (ERCC1 / ERCC2), increase the risk of cancer induced by smoking and alcohol consumption. This association is important considering that smoking and drinking alcohol are highly prevalent among the Chilean population.
dc.description.urihttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0370-41062018005000709&lng=en&nrm=iso&tlng=en
dc.identifier.citationRevista Chilena de Pediatria, 89(4), pp. 432-440.es
dc.identifier.issn0370-4106
dc.identifier.otherDOI: 10.4067/S0370-41062018005000709
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11154
dc.language.isoeses
dc.publisherSociedad Chilena de Pediatriaes
dc.subjectFarmacogenéticaes
dc.subjectCánceres
dc.subjectTabacoes
dc.subjectAlcoholes
dc.subjectFactores de Riesgoes
dc.subjectChilees
dc.titleFarmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cánceres
dc.title.alternativePharmacogenetics, tobacco, alcohol and its effect on the risk development canceres
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Roco_Farmacogenetica_tabaco.pdf
Tamaño:
1.08 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN ESPAÑOL
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista