Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells

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dc.contributor.authorAvilés, Evelyn C.
dc.contributor.authorPinto, Cristina
dc.contributor.authorHanna, Patricia
dc.contributor.authorOjeda, Jorge
dc.contributor.authorPérez, Viviana
dc.contributor.authorDe Ferrari, Giancarlo V.
dc.contributor.authorZamorano, Pedro
dc.contributor.authorAlbistur, Miguel
dc.contributor.authorSandoval, Daniel
dc.contributor.authorHenríquez, Juan P.
dc.date.accessioned2023-06-13T16:35:42Z
dc.date.available2023-06-13T16:35:42Z
dc.date.issued2014-04
dc.descriptionIndexación: Scopus.es
dc.description.abstractCumulative evidence indicates that Wnt pathways play crucial and diverse roles to assemble the neuromuscular junction (NMJ), a peripheral synapse characterized by the clustering of acetylcholine receptors (AChR) on postsynaptic densities. The molecular determinants of Wnt effects at the NMJ are still to be fully elucidated. We report here that the Wnt receptor Frizzled-9 (Fzd9) is expressed in developing skeletal muscles during NMJ synaptogenesis. In cultured myotubes, gain- and loss-of-function experiments revealed that Fzd9-mediated signaling impairs the AChR-clustering activity of agrin, an organizer of postsynaptic differentiation. Overexpression of Fzd9 induced the cytosolic accumulation of β-catenin, a key regulator of Wnt signaling. Consistently, Fzd9 and β-catenin localize in the postsynaptic domain of embryonic NMJs in vivo. Our findings represent the first evidence pointing to a crucial role of a Fzd-mediated, β-catenin-dependent signaling on the assembly of the vertebrate NMJ.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fncel.2014.00110/full
dc.identifier.citationFrontiers in Cellular Neuroscience. Volume 8, Issue 1 APR. 17 April 2014. Article number 110es
dc.identifier.doiDOI: 10.3389/fncel.2014.00110
dc.identifier.issn1662-5102
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/50616
dc.language.isoenes
dc.publisherFrontiers Research Foundationes
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectFrizzled Receptorses
dc.subjectWnt Proteinses
dc.subjectNeuromuscular Junctiones
dc.subjectAcetylcholine Receptores
dc.subjectPostsynaptices
dc.subjectSkeletal Musclees
dc.titleFrizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cellses
dc.typeArtículoes
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