TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death

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dc.contributor.authorRamírez Barrantes, R.
dc.contributor.authorCarvajal Zamorano K., K.
dc.contributor.authorRodríguez, B.
dc.contributor.authorCórdova, C.
dc.contributor.authorLozano, C.
dc.contributor.authorSimón, F.
dc.contributor.authorDíaz, P.
dc.contributor.authorMuñoz, P.
dc.contributor.authorMarchant, I.
dc.contributor.authorLatorre, R.
dc.contributor.authorCastillo, K.
dc.contributor.authorOlivero, P.
dc.date.accessioned2021-11-23T19:35:43Z
dc.date.available2021-11-23T19:35:43Z
dc.date.issued2020-05
dc.descriptionIndexación: Scopuses
dc.description.abstract17β-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype 1 (TRPV1) channel has been proposed as a steroid receptor implied in tissue protection against oxidative damage. We show here that TRPV1 is sufficient condition for 17β-estradiol to enhance metabolic performance in injured cells. Specifically, in TRPV1 expressing cells, the application of 17β-estradiol within the first 3 h avoided H2O2-dependent mitochondrial depolarization and the activation of caspase 3/7 protecting against the irreversible damage triggered by H2O2. Furthermore, 17β-estradiol potentiates TRPV1 single channel activity associated with an increased open probability. This effect was not observed after the application of 17α-estradiol. We explored the TRPV1-Estrogen relationship also in primary culture of hippocampal-derived neurons and observed that 17β-estradiol cell protection against H2O2-induced damage was independent of estrogen receptors pathway activation, membrane started and stereospecific. These results support the role of TRPV1 as a 17β-estradiol-activated ionotropic membrane receptor coupling with mitochondrial function and cell survival. © Copyright © 2020 Ramírez-Barrantes, Carvajal-Zamorano, Rodriguez, Cordova, Lozano, Simon, Díaz, Muñoz, Marchant, Latorre, Castillo and Olivero.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphys.2020.00444/full#S10
dc.identifier.citationFrontiers in PhysiologyOpen AccessVolume 1126 May 2020 Article number 444es
dc.identifier.doi10.3389/fphys.2020.00444
dc.identifier.issn1664-042X
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/21038
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject17β-estradioles
dc.subjectTRPV1es
dc.subjectNeuroprotectiones
dc.subjectMembrane receptores
dc.subjectCell deathes
dc.titleTRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Deathes
dc.typeArtículoes
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