Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways

Vista sencilla de ítem
dc.contributor.authorSimon, F.
dc.contributor.authorTapia, P.
dc.contributor.authorArmisen, R.
dc.contributor.authorEcheverria, C.
dc.contributor.authorGatica, S.
dc.contributor.authorVallejos, A.
dc.contributor.authorPacheco, A.
dc.contributor.authorSanhueza, M.E.
dc.contributor.authorAlvo, M.
dc.contributor.authorSegovia, E.
dc.contributor.authorTorres, R.
dc.date.accessioned2017-11-24T18:17:29Z
dc.date.available2017-11-24T18:17:29Z
dc.date.issued2017-06
dc.descriptionIndexación: Web of Science; Scopus.es_CL
dc.description.abstractChronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death. Despite this deleterious effect, the precise molecular mechanism of HPMC death as induced by HGH solutions is far from being understood. Therefore, the aim of this study was to explore the pathways involved in HGH solution-induced HPMC death. HGH-induced HPMC death included influxes of intracellular Ca2+ and Na+. Furthermore, HGH-induced HPMC death was inhibited by antioxidant and reducing agents. In line with this, HPMC death was induced solely by increased oxidative stress. In addition to this, the cPKC/NOX2 and PI3K/Akt intracellular signaling pathways also participated in HGH-induced HPMC death. The participation of PI3K/Akt intracellular is in agreement with previously shown in rat PMC apoptosis. These findings contribute toward fully elucidating the underlying molecular mechanism mediating peritoneal mesothelial cell death induced by high-glucose solutions during peritoneal dialysis.es_CL
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphys.2017.00379/full
dc.identifier.citationFrontiers in Physiology. Volume 8, Issue 13 June 2017, Article number 379es_CL
dc.identifier.issn1664-042X
dc.identifier.otherhttps://doi.org/10.3389/fphys.2017.00379
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/4737
dc.language.isoenes_CL
dc.publisherFrontiers Mediaes_CL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCell deathes_CL
dc.subjectDialysises_CL
dc.subjectHypertonicityes_CL
dc.subjectMesothelial celles_CL
dc.subjectPeritoneal tissuees_CL
dc.titleHuman peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathwayses_CL
dc.typeArtículoes_CL
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Simon_F_Human_Peritoneal_Mesothelial.pdf
Tamaño:
2.89 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista
FM - Artículos de Revista