Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies

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dc.contributor.authorGutiérrez-Vera, Cristián
dc.contributor.authorGarcía-Betancourt, Richard
dc.contributor.authorPalacios, Pablo A.
dc.contributor.authorMüller, Marioly
dc.contributor.authorMontero, David A.
dc.contributor.authorVerdugo, Carlos
dc.contributor.authorOrtiz, Francisca
dc.contributor.authorSimon, Felipe
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorSaavedra-Avila, Noemi A.
dc.contributor.authorPorcelli, Steven A.
dc.contributor.authorCarreño, Leandro J.
dc.date.accessioned2024-05-02T20:06:36Z
dc.date.available2024-05-02T20:06:36Z
dc.date.issued2024
dc.descriptionIndexación: Scopus.
dc.description.abstractAllergic asthma has emerged as a prevalent allergic disease worldwide, affecting most prominently both young individuals and lower-income populations in developing and developed countries. To devise effective and curative immunotherapy, it is crucial to comprehend the intricate nature of this condition, characterized by an immune response imbalance that favors a proinflammatory profile orchestrated by diverse subsets of immune cells. Although the involvement of Natural Killer T (NKT) cells in asthma pathology is frequently implied, their specific contributions to disease onset and progression remain incompletely understood. Given their remarkable ability to modulate the immune response through the rapid secretion of various cytokines, NKT cells represent a promising target for the development of effective immunotherapy against allergic asthma. This review provides a comprehensive summary of the current understanding of NKT cells in the context of allergic asthma, along with novel therapeutic approaches that leverage the functional response of these cells.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85190381750&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=13ffca5f702fe803ff87724c16a743a0&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID%28%22Universidad+Andr%c3%a9s+Bello%22+60002636%29+AND+SUBJAREA%28IMMU%29&relpos=11&citeCnt=0&searchTerm=
dc.description.urihttps://creativecommons.org/licenses/by/4.0/
dc.identifier.citationFrontiers in Immunology Open Access Volume 15 2024 Article number 1364774
dc.identifier.doi10.3389/fimmu.2024.1364774
dc.identifier.issn16643224
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56523
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.subjectallergic diseases
dc.subjectasthma
dc.subjectimmunomodulation
dc.subjectimmunotherapy
dc.subjectnatural killer T cells
dc.titleNatural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies
dc.typeArtículo
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