The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line

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dc.contributor.authorPistocchi, Anna
dc.contributor.authorFeijóo, Carmen G
dc.contributor.authorCabrera, Pablo
dc.contributor.authorVillablanca, Eduardo J
dc.contributor.authorAllende, Miguel L
dc.contributor.authorCotelli, Franco
dc.date.accessioned2024-06-05T17:37:42Z
dc.date.available2024-06-05T17:37:42Z
dc.date.issued2009
dc.descriptionINDEXACIÓN: SCOPUS.
dc.description.abstractBackground. The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells. Results. In this report we describe zebrafish prox1 mRNA expression in the migrating primordium and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1 we characterize expression of the protein in different cell types within neuromasts, and we show distribution among the supporting cells and hair cells. Conclusion. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts. © 2009 Pistocchi et al; licensee BioMed Central Ltd.
dc.identifier.citationBMC Developmental Biology, Volume 9, Issue 1, 2009, Article number 58
dc.identifier.doi10.1186/1471-213X-9-58
dc.identifier.issn1471-213X
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57346
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.rights.licenseCC BY 2.0 Attribution 2.0 Generic Deed
dc.rights.licensehttps://creativecommons.org/licenses/by/2.0/
dc.subjectAnimals
dc.subjectCell Differentiation
dc.subjectEmbryo, Nonmammalian
dc.subjectGene Expression Regulation, Developmental
dc.subjectHomeodomain Proteins
dc.subjectLateral Line System
dc.subjectMechanoreceptors
dc.subjectTumor Suppressor Proteins
dc.subjectZebrafish
dc.titleThe zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line
dc.typeArtículo
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