T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour

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dc.contributor.authorNuñez, Sarah
dc.contributor.authorSaez, Juan Jose
dc.contributor.authorFernandez, Dominique
dc.contributor.authorFlores-Santibañez, Felipe
dc.contributor.authorAlvarez, Karla
dc.contributor.authorTejon, Gabriela
dc.contributor.authorRuiz, Paulina
dc.contributor.authorMaldonado, Paula
dc.contributor.authorHidalgo, Yessia
dc.contributor.authorManriquez, Valeria
dc.contributor.authorBono, Maria Rosa
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorSauma, Daniela
dc.date.accessioned2025-05-16T14:29:37Z
dc.date.available2025-05-16T14:29:37Z
dc.date.issued2013
dc.descriptionIndexación: Scopus
dc.description.abstractT helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies; however, their function in tumour immunity is less clear. We explored possible opposing anti-tumour and tumour-promoting functions of Th17 cells by evaluating tumour growth and the ability to promote tumour infiltration of myeloid-derived suppressor cells (MDSC), regulatory T cells and CD4+ interferon-γ+ cells in a retinoic acid-like orphan receptor γt (RORγt) -deficient mouse model. A reduced percentage of Th17 cells in the tumour microenvironment in RORγt-deficient mice led to enhanced tumour growth, that could be reverted by adoptive transfer of Th17 cells. Differences in tumour growth were not associated with changes in the accumulation or suppressive function of MDSC and regulatory T cells but were related to a decrease in the proportion of CD4+ T cells in the tumour. Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses. © 2012 Blackwell Publishing Ltd.
dc.description.accesoabiertoSí
dc.description.agradProyectos ANID: This work was supported by Grants 3100077, 1100557 and 1100448 from Fondo Nacional de Desarrollo Cientifico y Tecnologico. G.T. and P.R. hold fellowships from Comision Nacional de Investigacion Cientifica y Tecnologica.
dc.description.urihttps://onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1111/imm.12055
dc.identifier.citationImmunology. Volume 139, Issue 1, Pages 61 - 71. May 2013
dc.identifier.doi10.1111/imm.12055
dc.identifier.folioFondo Nacional de Desarrollo Cientifico y Tecnologico. 3100077
dc.identifier.folioFondo Nacional de Desarrollo Científico y Tecnológico 1100557
dc.identifier.folioFondo Nacional de Desarrollo Científico y Tecnológico 1100448
dc.identifier.generoM
dc.identifier.issn1365-2567
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/64717
dc.language.isoen
dc.subjectAnti-tumour Immunity
dc.subjectRorγt
dc.subjectT helper type 1 cells
dc.subjectT helper type 17 cells
dc.titleT helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
dc.typeArtículo
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