Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

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dc.contributor.authorPrado, Yolanda
dc.contributor.authorEcheverría, Cesar
dc.contributor.authorFeijóo, Carmen G.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorSantibanez, Juan F.
dc.contributor.authorSimon, Felipe
dc.date.accessioned2023-07-14T23:43:54Z
dc.date.available2023-07-14T23:43:54Z
dc.date.issued2023-03
dc.descriptionIndexación: Scopuses
dc.description.abstractSepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment. © 2023 by the authors.es
dc.description.urihttps://www.mdpi.com/2076-3921/12/3/659
dc.identifier.citationAntioxidants Volume 12, Issue 3March 2023 Article number 659es
dc.identifier.doi10.3390/antiox12030659
dc.identifier.issn2076-3921
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51674
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectEndotheliumes
dc.subjectFatty acidses
dc.subjectFibrosises
dc.subjectFood supplementses
dc.subjectHyperpermeabilityes
dc.subjectMortalityes
dc.subjectOrgan functiones
dc.subjectPolyphenolic antioxidant flavonoidses
dc.subjectSepsises
dc.titleEffect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Ratses
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