Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex

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dc.contributor.authorStehberg, Jimmy
dc.contributor.authorDang, Phat T.
dc.contributor.authorFrostig, Ron D.
dc.date.accessioned2023-01-10T15:32:23Z
dc.date.available2023-01-10T15:32:23Z
dc.date.issued2014
dc.descriptionIndexación: Scopuses
dc.description.abstractResearch based on functional imaging and neuronal recordings in the barrel cortex subdivision of primary somatosensory cortex (SI) of the adult rat has revealed novel aspects of structure-function relationships in this cortex. Specifically, it has demonstrated that single whisker stimulation evokes subthreshold neuronal activity that spreads symmetrically within gray matter from the appropriate barrel area, crosses cytoarchitectural borders of SI and reaches deeply into other unimodal primary cortices such as primary auditory (AI) and primary visual (VI). It was further demonstrated that this spread is supported by a spatially matching underlying diffuse network of border-crossing, long-range projections that could also reach deeply into AI and VI. Here we seek to determine whether such a network of border-crossing, long-range projections is unique to barrel cortex or characterizes also other primary, unimodal sensory cortices and therefore could directly connect them. Using anterograde (BDA) and retrograde (CTb) tract-tracing techniques, we demonstrate that such diffuse horizontal networks directly and mutually connect VI, AI and SI. These findings suggest that diffuse, border-crossing axonal projections connecting directly primary cortices are an important organizational motif common to all major primary sensory cortices in the rat. Potential implications of these findings for topics including cortical structure-function relationships, multisensory integration, functional imaging, and cortical parcellation are discussed. © 2014 Stehberg, Dang and Frostig.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnana.2014.00093/full
dc.identifier.doi10.3389/fnana.2014.00093
dc.identifier.issn1662-5129
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/35947
dc.language.isoenes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAnterogradees
dc.subjectBDAes
dc.subjectBorder-crossinges
dc.subjectCTbes
dc.subjectLong-range projectionses
dc.subjectMultisensory integrationes
dc.subjectPrimary sensory cortexes
dc.subjectRetrogradees
dc.titleUnimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortexes
dc.typeArtículoes
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Frontiers in Neuroanatomy Volume 8, Issue SEP24 September 2014 Article number 93
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