Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

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dc.contributor.authorGatica, Sebastian
dc.contributor.authorFuentes, Brandon
dc.contributor.authorRivera-Asín, Elizabeth
dc.contributor.authorRamírez-Céspedes, Paula
dc.contributor.authorSepúlveda-Alfaro, Javiera
dc.contributor.authorCatalán, Eduardo A.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorSimon, Felipe
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorMelo-Gonzalez, Felipe
dc.date.accessioned2024-05-10T21:21:22Z
dc.date.available2024-05-10T21:21:22Z
dc.date.issued2023
dc.descriptionIndexación: Scopus
dc.description.abstractSepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis. Copyright © 2023 Gatica, Fuentes, Rivera-Asín, Ramírez-Céspedes, Sepúlveda-Alfaro, Catalán, Bueno, Kalergis, Simon, Riedel and Melo-Gonzalez.
dc.description.urihttps://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1198200/full
dc.identifier.citationFrontiers in Microbiology. Volume 14. 2023. Article number 1198200
dc.identifier.doi10.3389/fmicb.2023.1198200
dc.identifier.issn1664-302X
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56683
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDiagnostics
dc.subjectImmunology
dc.subjectInflammation
dc.subjectMicroorganisms
dc.subjectPrognosis
dc.subjectSepsis
dc.subjectTherapy
dc.titleNovel evidence on sepsis-inducing pathogens: from laboratory to bedside
dc.typeArtículo
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