Effects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineering

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dc.contributor.authorOlguín, Y.
dc.contributor.authorCampos, C.
dc.contributor.authorCatalán, J.
dc.contributor.authorVelásquez, L.
dc.contributor.authorOsorio, F.
dc.contributor.authorMontenegro, I.
dc.contributor.authorMadrid, A.
dc.contributor.authorAcevedo, C.
dc.date.accessioned2018-03-14T14:41:27Z
dc.date.available2018-03-14T14:41:27Z
dc.date.issued2017-09
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractAdvances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes. The rheological and thermal properties and their relation with the neurite proliferation and growth of the PC12 cell line were evaluated. Our results show that the incorporation of liposomes modifies the properties of the hydrogels dependent on the concentration of chitosan and the lipid type in the liposomes, which directly affect the capabilities of the hydrogels to promote the viability and differentiation of PC12 cells. © 2017 by the authors.es_ES
dc.description.urihttp://www.mdpi.com/1996-1944/10/10/1122
dc.identifier.citationMaterials. Volume 10, Issue 10, 22 September 2017, Article number 1122es_ES
dc.identifier.issn1996-1944
dc.identifier.otherDOI: 10.3390/ma10101122
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/5433
dc.language.isoenes_ES
dc.publisherMDPI AGes_ES
dc.subjectEffect of Liposomeses_ES
dc.subjectGrowth of neurites PC12 cellses_ES
dc.subjectPluronic F127/Chitosan hydrogelses_ES
dc.titleEffects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineeringes_ES
dc.typeArtículoes_ES
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