Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring

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dc.contributor.authorMoraga-Amaro, Rodrigo
dc.contributor.authorDíaz-Galarce, Raul
dc.contributor.authorDonoso-Ramos, Juan P.
dc.contributor.authorUgalde, Valentina
dc.contributor.authorLinsambarth, Sergio
dc.contributor.authorDoorduin, Janine
dc.contributor.authorde Vries, Erik FJ.
dc.contributor.authorAmpuero, Estibaliz
dc.contributor.authorPeña, Francisca
dc.contributor.authorPacheco, Rodrigo
dc.contributor.authorWyneken, Ursula
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2025-04-21T15:08:12Z
dc.date.available2025-04-21T15:08:12Z
dc.date.issued2021-10-01
dc.descriptionIndexación: Scopus.
dc.description.abstractFluoxetine is often prescribed to treat depression during pregnancy. Rodent studies have shown that fluoxetine exposure during early development can induce persistent changes in the emotional behavior of the offspring. However, the effects of prenatal fluoxetine on memory have not been elucidated. This study evaluates the memory of adult male offspring from rat dams orally administered with a clinically relevant dose of 0.7 mg/kg fluoxetine from 9 weeks before pregnancy to 1 week before delivery. Hippocampal-dependent (Morris Water Maze, MWM) and non-hippocampal-dependent (Novel Object Recognition, NOR) memory paradigms were assessed. Anxiety- and depressive-like symptoms were also evaluated using the Open Field Test, Tail Suspension Test and Sucrose Preference Test. Male rats exposed to fluoxetine during gestation displayed NOR memory impairments during adulthood, as well as increased anxiety- and depressive-like symptoms. In the MWM, the offspring of fluoxetine-treated dams did not show learning deficits. However, a retention impairment was found on remote memory, 15 days after the end of training. Molecular analyses showed increased expression of NMDA subunit NR2B, and a decrease in NR2A-to- NR2B ratio in the temporal cortex, but not in the hippocampus, suggesting changes in NMDA receptor composition. These results suggest that in utero exposure to fluoxetine induces detrimental effects on non-hippocampal memory and in remote retention of hippocampal-dependent memory, which is believed to be stored in the temporal cortex, possibly due to changes in cortical NMDA receptor subunit stoichiometry. The present results warrant the need for studies on potential remote memory deficits in human offspring exposed to fluoxetine in utero. © 2021 Elsevier Ltd
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0028390821003063?via%3Dihub
dc.identifier.citationNeuropharmacology, Volume 197, 1 October 2021, Article number 108751
dc.identifier.doi10.1016/j.neuropharm.2021.108751
dc.identifier.issn0028-3908
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/64232
dc.language.isoen
dc.publisherNEPHB
dc.rights.licenseAtribución/Reconocimiento-NoComercial-SinDerivados 4.0 Internacional CC BY-NC-ND 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectFluoxetine
dc.subjectIn utero
dc.subjectMemory impairment
dc.subjectNR2B
dc.subjectOffspring
dc.subjectPregnancy
dc.subjectRemote memory
dc.subjectRetention deficit
dc.subjectTemporal cortex
dc.titlePrenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring
dc.typeArtículo
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