Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru

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dc.contributor.authorBenavides, J.
dc.contributor.authorGodreuil, S.
dc.contributor.authorOpazo-Capurro, E.
dc.contributor.authorMahamat, O.
dc.contributor.authorFalcon, N.
dc.contributor.authorOravcova, K.
dc.contributor.authorStreicker, D.
dc.contributor.authorShiva, C.
dc.date.accessioned2022-08-01T16:42:38Z
dc.date.available2022-08-01T16:42:38Z
dc.date.issued2022-03
dc.descriptionIndexación: Scopus.es
dc.description.abstractExtended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) have been reported in wildlife worldwide. Whether wildlife is a transient host of ESBL-E. coli or comprises an independently maintained reservoir is unknown. We investigated this question by longitudinally monitoring ESBL-E. coli in common vampire bats and nearby livestock in Peru. Among 388 bats from five vampire bat colonies collected over three years, ESBL-E. coli were detected at a low prevalence (10% in 2015, 4% in 2017 and 2018) compared to a high prevalence (48%) from 134 livestock sampled in 2017. All ESBL-E. coli were multidrug-resistant, and whole genome sequencing of 33 randomly selected ESBL-E. coli isolates (18 recovered from bats) detected 46 genes conferring resistance to antibiotics including third-generation cephalosporins (e.g., blaCTX-M-55, blaCTX-M-15, blaCTX-M-65, blaCTX-M-3, blaCTX-M-14), aminoglycosides, fluoroquinolones, and colistin (mcr-1). The mcr-1 gene is reported for the first time on a wild bat in Latin America. ESBL-E. coli also carried 31 plasmid replicon types and 16 virulence genes. Twenty-three E. coli sequence types (STs) were detected, including STs involved in clinical infections worldwide (e.g., ST 167, ST 117, ST 10, ST 156 and ST 648). ESBL-E. coli with identical cgMLST (ST 167) were detected in the same bat roost in 2015 and 2017, and several ESBL-E. coli from different bat roosts clustered together in the cgMLST reconstruction, suggesting long-term maintenance of ESBL-E. coli within bats. Most antibiotic resistance and virulence genes were detected in E. coli from both host populations, while ESBL-E. coli ST 744 was found in a bat and a pig from the same locality, suggesting possible cross-species exchanges of genetic material and/or bacteria between bats and livestock. This study suggests that wild mammals can maintain multidrug-resistant bacteria and share them with livestock.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0048969721071217?via%3Dihub
dc.identifier.citationScience of the Total Environment, Volume 8101, March 2022, Article number 152045es
dc.identifier.doi10.1016/j.scitotenv.2021.152045
dc.identifier.issn0048-9697
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23382
dc.language.isoenes
dc.publisherElsevier B.V.es
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S0048969721071217&orderBeanReset=true
dc.subjectAntimicrobial resistancees
dc.subjectE. colies
dc.subjectExtended-spectrum beta-lactamasees
dc.subjectLatin Americaes
dc.subjectmcr-1es
dc.subjectWildlifees
dc.titleLong-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Perues
dc.typeArtículoes
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