SARS-CoV-2/renin-angiotensin system: Deciphering the clues for a couple with potentially harmful effects on skeletal muscle

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dc.contributor.authorGonzalez A.
dc.contributor.authorOrozco-Aguilar J.
dc.contributor.authorAchiardi O.
dc.contributor.authorSimon F.
dc.contributor.authorCabello-Verrugio C.
dc.date.accessioned2021-11-09T18:55:06Z
dc.date.available2021-11-09T18:55:06Z
dc.date.issued2020-11
dc.descriptionIndexación Scopuses
dc.description.abstractSevere acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. A high proportion of patients require intensive care unit admission and mechanical ventilation (MV) to survive. It has been well established that angiotensin-converting enzyme type 2 (ACE2) is the primary cellular receptor for SARS-CoV-2. ACE2 belongs to the renin-angiotensin system (RAS), composed of several peptides, such as angiotensin II (Ang II) and angiotensin (1-7) (Ang-(1-7)). Both peptides regulate muscle mass and function. It has been described that SARS-CoV-2 infection, by direct and indirect mechanisms, affects a broad range of organ systems. In the skeletal muscle, through unbalanced RAS activity, SARS-CoV-2 could induce severe consequences such as loss of muscle mass, strength, and physical function, which will delay and interfere with the recovery process of patients with COVID-19. This article discusses the relationship between RAS, SARS-CoV-2, skeletal muscle, and the potentially harmful consequences for skeletal muscle in patients currently infected with and recovering from COVID-19. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.es
dc.description.urihttps://www.mdpi.com/1422-0067/21/21/7904
dc.identifier.citationInternational Journal of Molecular Sciences, Volume 21, Issue 21, Pages 1 - 181 November 2020 Article number 7904es
dc.identifier.doi10.3390/ijms21217904
dc.identifier.issn16616596
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/20819
dc.language.isoenes
dc.publisherMDPI AGes
dc.subjectAngiotensin I (1-7)es
dc.subjectAngiotensin Converting Enzyme 2es
dc.subjectAlamandinees
dc.titleSARS-CoV-2/renin-angiotensin system: Deciphering the clues for a couple with potentially harmful effects on skeletal musclees
dc.typeArtículoes
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