Retinoic acid as a modulator of T cell immunity

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dc.contributor.authorBono, M.R.
dc.contributor.authorTejon, G.
dc.contributor.authorFlores-Santibañez, F
dc.contributor.authorFernandez, D.
dc.contributor.authorRosemblatt, M.
dc.contributor.authorSauma, D.
dc.date.accessioned2016-06-23T13:45:53Z
dc.date.available2016-06-23T13:45:53Z
dc.date.issued2016
dc.descriptionIndexación: Scopus. DOAJ.es
dc.description.abstractVitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system, maintenance of cell function and differentiation, epithelial surface integrity, erythrocyte production, reproduction, and normal immune function. Vitamin A deficiency is one of the most common micronutrient deficiencies worldwide and is associated with defects in adaptive immunity. Reports from epidemiological studies, clinical trials and experimental studies have clearly demonstrated that vitamin A plays a central role in immunity and that its deficiency is the cause of broad immune alterations including decreased humoral and cellular responses, inadequate immune regulation, weak response to vaccines and poor lymphoid organ development. In this review, we will examine the role of vitamin A in immunity and focus on several aspects of T cell biology such as T helper cell differentiation, function and homing, as well as lymphoid organ development. Further, we will provide an overview of the effects of vitamin A deficiency in the adaptive immune responses and how retinoic acid, through its effect on T cells can fine-tune the balance between tolerance and immunity.es
dc.description.urihttp://www.mdpi.com/2072-6643/8/6/349
dc.identifier.citationNutrients 2016, 8(6), 349es
dc.identifier.issn2072-6643
dc.identifier.otherdoi:10.3390/nu8060349
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/834
dc.language.isoenes
dc.publisherMDPI AGes
dc.subjectRetinoic acides
dc.subjectVitamin Aes
dc.subjectT celles
dc.subjectOral tolerancees
dc.subjectHominges
dc.titleRetinoic acid as a modulator of T cell immunityes
dc.typeArtículoes
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