Psychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia

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dc.contributor.authorSobregrau, Pau
dc.contributor.authorPeri, Josep M.
dc.contributor.authorSánchez Del Valle, Raquel
dc.contributor.authorMolinuevo, Jose L.
dc.contributor.authorBarra, Bernardo
dc.contributor.authorPintor, Luís
dc.date.accessioned2024-11-05T17:14:23Z
dc.date.available2024-11-05T17:14:23Z
dc.date.issued2022
dc.descriptionIndexación: Scopus.
dc.description.abstractBackground: Predictive genetic tests are presently effective over several medical conditions, increasing the demand among patients and healthy individuals. Considering the psychological burden suspected familial dementia may carry on individuals, assessing personality, coping strategies, and mental health could aid clinicians in findings the appropriate time for delivering genetic test results and predict compliance regarding genetic counseling and expectations towards the genetic condition depending on the outcome. Objective: To describe the psychiatric, psychological, and coping characteristics of a sample of Spanish individuals at risk of familial dementia before genetic test results were given. Methods: We included 54 first degree relatives of patients diagnosed with Alzheimer's disease, lobar frontotemporal degeneration, or prion diseases. The NEO-FFI-R, COPE, and HADS tests evaluated personality, coping strategies, and psychological distress, respectively. Results: Anxiety and depression were below the cut-off point for mild severity. Conscientiousness and Agreeableness were the most preponderant personality factors, while Neuroticism was the least. Positive reinterpretation and Acceptance were the most frequent coping strategies, and Denial and Alcohol and drug use were the least used. Ongoing medical pathologies increased depression, while psychiatric disorders worsened psychological distress. Conclusion: Contrary to our expectations, PICOGEN candidates showed psychological distress and personality traits within normative ranges, and the use of problem-focused coping strategies prevailed over avoidance coping strategies. Nevertheless, clinicians should pay particular attention to individuals attending genetic counseling who are women, aged, and present an ongoing psychiatric disorder and psychiatric history at inclusion to ensure their mental health and adherence throughout the process. © 2022 - The authors. Published by IOS Press.
dc.description.urihttps://content.iospress.com/articles/journal-of-alzheimers-disease-reports/adr210067
dc.identifier.citationJournal of Alzheimer's Disease Reports, Volume 6, Issue 1, Pages 461 - 478, 2022
dc.identifier.doi10.3233/ADR-210067
dc.identifier.issn2542-4823
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/61733
dc.language.isoen
dc.publisherIOS Press BV
dc.rights.licenseAtribución/Reconocimiento-NoComercial 4.0 Internacional CC BY-NC 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subjectAlzheimer's disease
dc.subjectDementia
dc.subjectFrontotemporal lobar degeneration
dc.subjectGenetic counseling
dc.subjectGenetic testing
dc.subjectNeurodegenerative diseases
dc.subjectPrion diseases
dc.subjectPsychiatry
dc.subjectPsychology
dc.titlePsychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia
dc.typeArtículo
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