KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

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dc.contributor.authorTapia, Diego
dc.contributor.authorJiménez, Tomás
dc.contributor.authorZamora, Constanza
dc.contributor.authorEspinoza, Javier
dc.contributor.authorRizzo, Riccardo
dc.contributor.authorGonzález-Cárdenas, Alexis
dc.contributor.authorFuentes, Danitza
dc.contributor.authorHernández, Sergio
dc.contributor.authorCavieres, Viviana A.
dc.contributor.authorSoza, Andrea
dc.contributor.authorGuzmán, Fanny
dc.contributor.authorArriagada, Gloria
dc.contributor.authorYuseff, María Isabel
dc.contributor.authorMardones, Gonzalo A.
dc.contributor.authorBurgos, Patricia V.
dc.contributor.authorLuini, Alberto
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorCancino, Jorge
dc.date.accessioned2021-11-08T20:10:07Z
dc.date.available2021-11-08T20:10:07Z
dc.date.issued2019-12
dc.descriptionIndexación: Scopuses
dc.description.abstractInter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion. © 2019, The Author(s).es
dc.description.urihttps://www-nature-com.recursosbiblioteca.unab.cl/articles/s41467-019-08501-w.pdf
dc.identifier.citationNature Communications Volume 10, Issue 11 December 2019 Article number 735es
dc.identifier.doi10.1038/s41467-019-08501-w
dc.identifier.issn2041-1723
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/20802
dc.language.isoenes
dc.publisherNature Publishing Groupes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAutophagyes
dc.subjectCell Line, Tumores
dc.subjectCell Nucleuses
dc.subjectDyneinses
dc.subjectEndoplasmic Reticulumes
dc.subjectGolgi Apparatuses
dc.subjectHeLa Cellses
dc.subjectHumanses
dc.subjectLipid Dropletses
dc.subjectLysosomeses
dc.subjectMicroscopy, Electron, Transmissiones
dc.subjectMicrotubuleses
dc.subjectProtein Transportes
dc.subjectReceptors, Peptidees
dc.subjectSequestosome-1 Proteines
dc.subjectSignal Transductiones
dc.titleKDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnoveres
dc.typeArtículoes
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